Project Grant R21HD115343

Award Date 9/4/24
Completion Date 8/31/26
Dollars Obligated $275K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Rhode Island, USA
Similar Awards
This federal Project Grant award, provided by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), will support a research project conducted by Teachers College Columbia University that seeks to examine the longitudinal associations among maternal stress, accelerated epigenetic aging, and cognitive and behavioral development in early childhood. The $127,722 award, spanning from December 2024 to March 2025, will...
This $235,564 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research at Duke University to study the long-term health consequences of childhood maltreatment and foster care placement from adolescence into mid-life. The project will leverage data from the National Longitudinal Study of Adolescent to Adult Health to (1) extend the scope of existing...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to investigate epigenetic pathways connecting childhood socioeconomic conditions to physical and cognitive health outcomes across the lifespan. The $2,307,994 grant will fund a study integrating DNA methylation profiles as a "molecular wormhole" to examine the impact of childhood environments, including the effects of...
The National Institute of Child Health and Human Development (NICHD) awarded a 5-year, $1.89M Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of California, Irvine. The grant supports a short-term longitudinal experimental study examining the effects of acute stress on memory performance between maltreated and non-maltreated 12-17-year-old youth. The research aims to provide insights into how maltreatment shapes youth's...
This Project Grant award of $225,306.00 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a secondary data analysis study at the University of North Carolina at Chapel Hill. The study aims to explore the mediating pathways by which maternal childhood maltreatment (CM) may increase the risk of externalizing and internalizing psychopathology among adolescent offspring. The...
This Project Grant award of $165,000.00 from the National Science Foundation's (NSF) Social, Behavioral, and Economic Sciences (CFDA 47.075) program supports an early career postdoctoral researcher studying the relationship between early-life adversity (ELA) and biological aging. The research aims to use epigenetic clocks to prospectively examine how ELA and associated life history trade-offs impact the pace of biological aging from early to middle adulthood. The research will leverage data from...
This $176,255 federal Project Grant awarded by the National Institute of Child Health and Human Development (CFDA Program 93.865 - Child Health and Human Development Extramural Research) aims to assess how social contextual stressors over the maternal pre-pregnancy life course contribute to racial inequities in maternal and infant health outcomes in the United States. The study will use longitudinal data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to...
This $200,310 project grant from the Department of Health and Human Services' National Institutes of Health National Institute on Aging will fund research into the differential impact of adverse childhood experiences and aging on brain health. Specifically, the Oklahoma State University grant will pursue two aims: 1) characterize cognitive performance across emerging and older adult cohorts stratified by ACEs, and 2) characterize brain-derived neurotrophic factor levels across the two age...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to elucidate the relationships among mothers' adverse childhood experiences (ACEs), positive childhood experiences (PCEs), maternal sensitivity, and immune regulation in infants and toddlers of mothers living with opioid dependence. The $803,701.38 award, with a performance period of August 1, 2024 to July...
This $134,568 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify the cognitive neural signatures of childhood maltreatment in adolescents. The primary goal is to develop a mechanistic theory and mechanism-targeted interventions to address the adverse cognitive consequences of childhood maltreatment and translate neuroscience findings to...

This Project Grant award of $274,595.00 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research at Emma Pendleton Bradley Hospital, a non-profit psychiatric hospital, to investigate the biological mechanisms linking childhood adversity and accelerated aging.

The research aims to explore how early life stress, including childhood maltreatment and trauma, may alter mitochondrial DNA and function, potentially contributing to increased risk for stress-related and age-related health conditions such as psychiatric disorders, obesity, diabetes, and cardiovascular disease. The project leverages longitudinal data and biospecimens from an existing study on childhood maltreatment to provide insight into the biological underpinnings of adversity-related risks for accelerated aging and disease development. Findings from this research are expected to inform new treatment and prevention approaches targeting these mechanisms.

Generated 6/24/25, 5:32 AM