This $794,978 Project Grant award from the National Institute on Aging's Aging Research Program (CFDA 93.866) will support a longitudinal study on the impact of individual and community-level socioeconomic disadvantage across the lifespan on cognitive function and decline in midlife. The project aims to examine accelerated epigenetic aging as a biological mechanism connecting socioeconomic disadvantage to poorer cognitive outcomes. The University of Pittsburgh will leverage existing data from...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to examine the associations between early and later-life stress on later-life cognition and plasma biomarkers of Alzheimer's disease and related dementias (ADRD). The $195,896 award, provided to Wake Forest University Health Sciences, will fund a cross-sectional study to assess whether sex modifies these associations among participants without dementia. The research team will receive training in...
The National Institute on Aging (NIA) awarded a $5,272,845 Project Grant (CFDA 93.866 - Aging Research) to the University of Southern California (USC) to study the long-term effects of educational investments on cognitive health. The project aims to leverage a natural experiment from the National Defense Education Act (NDEA) in the 1950s-60s to evaluate the causal impacts of K-12 and college educational experiences on late-life cognitive function. USC will collaborate with Emory University, RAND...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $769,710 will support research to examine the impact of upward socioeconomic mobility during adolescence on cognitive health and Alzheimer's disease (AD) risk factors in young adulthood. The project will leverage an existing cohort from the Reducing Inequities through Social and Educational Change Follow-up (RISE-UP) study to compare young adults who had the opportunity for greater...
This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
This $654,238 Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to investigate the role of senescent cells in brain aging and the development of Alzheimer's disease and related dementias (ADRD). The project aims to generate high-resolution spatial omics data from ADRD brains and mouse models to identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons. The work will be conducted by...
This $295,000 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports Neurogeneces, Inc., a small business, in developing a machine learning algorithm to assess "brain age" from at-home EEG sleep data. The goal is to provide an objective, interpretable measure of age-adjusted brain function that can facilitate early detection of cognitive decline. Through this Phase I Small Business Technology Transfer (STTR) project, Neurogeneces will...
This $6.18 million project grant from the National Institutes of Health's National Institute on Aging will fund the University of Texas at Austin to conduct the first large-scale genomic analysis of continuous rates of longitudinal aging-related cognitive change prior to dementia onset. Working with sub-awardees the University of Colorado and the University of Edinburgh, the researchers will identify genetic variants beyond APOE that confer risk for cognitive decline leading to eventual...
This federal Project Grant award for $729,567, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund a study to investigate the causal impacts of two key childhood environmental conditions - school quality and infectious disease exposure - on adult health and mortality outcomes. The study aims to construct a novel dataset linking individual-level childhood environment factors to longevity, in order to examine how these modifiable conditions affect schooling,...
This federal Project Grant award, provided by the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research, aims to examine the role of the environmental exposome as a risk factor for Alzheimer's disease (AD) among non-Hispanic Whites, African Americans, and Mexican Americans. The $1,205,827 award to the University of Texas Southwestern Medical Center will utilize blood samples from 3,000 participants in the ongoing Health & Aging Brain Study - Health Disparities Study...
This $200,310 project grant from the Department of Health and Human Services' National Institutes of Health National Institute on Aging will fund research into the differential impact of adverse childhood experiences and aging on brain health. Specifically, the Oklahoma State University grant will pursue two aims: 1) characterize cognitive performance across emerging and older adult cohorts stratified by ACEs, and 2) characterize brain-derived neurotrophic factor levels across the two age cohorts stratified by ACEs.
Using an observational cohort design, the grantee will recruit 100 adults - 50 emerging adults and 50 older adults - in independent groups matched by ACE exposure and other key covariates like education. Participants will complete an online screening and, for older adults, an additional in-lab screening. Eligible and consenting participants will have blood drawn before completing a computerized cognitive assessment including the Automated Neuropsychological Assessment Metrics and NIH Toolbox Cognitive Battery. This research under the Aging Research (93.866) program aims to identify novel risk factors for brain health promotion and healthy aging across the lifespan.