Project Grant R21HD113796

Award Date 9/19/23
Completion Date 8/31/25
Dollars Obligated $429K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Aurora, CO 80045, USA
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This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 Child Health and Human Development Extramural Research provides $429,000.00 to the University of Colorado-Denver for a 2-year project to develop optogenetic and chemogenetic models to regulate uterine vascular function and prevent fetal growth restriction (FGR).

The key products and services to be delivered through this award include:

  • Establishing mouse models expressing light-activated opsins or modified receptors in the uterine artery smooth muscle or endothelium to enable selective manipulation of uterine blood flow
  • Demonstrating the capacity for light stimulation or pharmacological activation to vasodilate the uterine artery and increase blood flow, with the goal of preventing hypoxia-induced FGR
  • Validating these novel optogenetic and chemogenetic approaches as reliable in vivo models for studying mechanisms to improve uteroplacental vascular function and fetal growth

This research aims to provide a foundational framework for applying optogenetic and chemogenetic techniques to investigate vascular regulation in other contexts beyond the uterine vasculature.

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