This Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate how the gut microbiome composition impacts gastrointestinal (GI) and central nervous system (CNS) function in a mouse model of autism spectrum disorder (ASD). The $430,375 award to the partnership between Henry Ford Health and Michigan State University Health Sciences will fund a 2-year study with the following key objectives: Determine if different gut microbiome compositions (specific pathogen-free, Bifidobacterium-dominated, or Bacteroides-dominated) moderate the effects of prenatal valproic acid exposure on GI function in mice, as assessed through measures of colonic transit, intestinal permeability, neurotransmission, and inflammation. Evaluate whether gut microbiome composition moderates the impact of prenatal valproic acid exposure on CNS structure and function in mice, including behavioral assessments and analysis of neuroinflammation, dendritic morphology, and myelination in key brain regions. The research aims to enhance understanding of the gut microbiome's role in GI and CNS processes relevant to ASD, and to facilitate the development of novel microbiome-based interventions to address core ASD symptoms and comorbidities. As a sub-awardee, the partnership will contribute to this research through its expertise and access to specialized facilities.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $430.4k | 9/12/23 |