Project Grant R21HD112101

Award Date 9/12/23
Completion Date 8/31/25
Dollars Obligated $430K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
East Lansing, MI 48824, USA
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The federal Project Grant award from the National Institute of Child Health and Human Development (under CFDA 93.865 - Child Health and Human Development Extramural Research) in the amount of $340,604.00 will support the development, refinement, and psychometric evaluation of four autism-specific gastrointestinal (GI) symptom measurement questionnaires. The research team at the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. will work with community participants to generate and...
This federal Project Grant award of $637,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to investigate the role of "microbially conjugated bile acids" (MCBAs) produced by the gut microbiome and their impact on gut inflammation. The key objectives are to: 1) define the microbiology of MCBA production and their resistance to hydrolysis, 2) determine the agonist...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will support research to investigate the mechanisms underlying gastrointestinal dysfunction in Down syndrome (DS). The $232,875 award to Virginia Commonwealth University will fund a 2-year research project to study smooth muscle function and voltage-gated calcium channels in the distal colon of a DS mouse model. The research plan...
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This Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate how the gut microbiome composition impacts gastrointestinal (GI) and central nervous system (CNS) function in a mouse model of autism spectrum disorder (ASD). The $430,375 award to the partnership between Henry Ford Health and Michigan State University Health Sciences will fund a 2-year study with the following key objectives:

  1. Determine if different gut microbiome compositions (specific pathogen-free, Bifidobacterium-dominated, or Bacteroides-dominated) moderate the effects of prenatal valproic acid exposure on GI function in mice, as assessed through measures of colonic transit, intestinal permeability, neurotransmission, and inflammation.

  2. Evaluate whether gut microbiome composition moderates the impact of prenatal valproic acid exposure on CNS structure and function in mice, including behavioral assessments and analysis of neuroinflammation, dendritic morphology, and myelination in key brain regions.

The research aims to enhance understanding of the gut microbiome's role in GI and CNS processes relevant to ASD, and to facilitate the development of novel microbiome-based interventions to address core ASD symptoms and comorbidities. As a sub-awardee, the partnership will contribute to this research through its expertise and access to specialized facilities.

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