Project Grant R21GM166477
- The National Institute of General Medical Sciences awarded The Rockefeller University $395,499 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for research into cytoskeletal force-sensing mechanisms underlying mechanotransduction. The research develops innovative cryo-electron microscopy sample preparation and machine-learning computational analysis approaches to uncover force-dependent structural transitions in F-actin (actin filaments) elicited by...
- The National Institute of General Medical Sciences awarded $398,464 to the University of Oregon on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop photoresponsive biomaterials for directing the growth and differentiation of three-dimensional microphysiological tissue systems. The project focuses on creating smart, light-triggered biomaterials that provide spatial and temporal control over cell growth and differentiation in engineered tissues. The...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Rochester $226,625 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a tandem-chip microphysiological system for assessing cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome in immunotherapy patients. The recipient will engineer an integrated drug development tool...
- The National Institute of General Medical Sciences awarded the University of Southern California $456,500 on September 1, 2026, through the Biomedical Research and Research Training program (CFDA 93.859) to decode and remotely reprogram cellular signaling networks. Work will extend through August 31, 2031, performed in Los Angeles, California. The recipient will develop multiplexed single-fluorophore biosensors to simultaneously visualize multiple signaling activities—including tyrosine kinase...
- The National Institute of General Medical Sciences awarded N.p. Photonics, Inc., a Tucson, Arizona-based small business, $306,873 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to develop a low-cost robust compact 900 nanometer femtosecond laser source for two-photon microscopy, featuring ultrashort pulse lasers with peak powers exceeding 1 kilowatt and specified pulse durations. The award obligates $306,873 and runs through August 31, 2027,...
- The National Institute of Neurological Disorders and Stroke awarded the University of Rochester $226,500 on January 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular mechanisms of TARP modulation of AMPA receptor gating. The research combines non-canonical amino acid crosslinking and patch clamp fluorometry to identify contact sites between the B1-2 extracellular loop of TARP proteins G2 and G8 and...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded 37Degrees, Inc. $360,247 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type: Project Grant). The award funds development of photoacoustic microscopy systems for non-destructive, three-dimensional imaging of live and incubated engineered tissue. The project addresses a critical gap in...
- The National Institute of General Medical Sciences awarded the University of Rochester $578,733 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate the biological roles of tRNA modification enzymes. The award funds research combining biochemistry, molecular biology, and genetics to resolve knowledge gaps about how tRNA modifications impact tRNA structure and function, the roles of vertebrate-specific tRNA modification enzymes, and how these...
- The National Institute of General Medical Sciences (NIGMS) awarded $369,000 to Princeton University on June 1, 2026, under CFDA 93.859 (Biomedical Research and Research Training) to support optogenetic tools and biosensor development for studying intracellular signaling and cellular decision-making. The Toettcher Laboratory at Princeton will develop cutting-edge optogenetic tools and biosensors to probe and manipulate cells' internal states over the five-year performance period ending May 31,...
- The National Institute of General Medical Sciences awarded the University of Rochester $448,196 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop synthetic tools for constructing carbon-nitrogen bonds using N-aryl and N-alkenyl nitrogen intermediates. The research targets the synthesis of nitrogen heterocycles, which are critical structural components in pharmaceuticals and natural products. The project will develop catalytic methods to...
The National Institute of General Medical Sciences awarded the University of Rochester $399,475 on September 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and validate photoacoustic stimulation as a tool for non-contact, label-free activation of the somatosensory system in cells and animals. The project develops a method in which pulsed light absorbed by tissue or dye sensitizers generates localized mechanical forces that activate ion channels, addressing the limitation of current tactile stimulation methods—mechanical actuators, vibration motors, and electrical stimulation—which lack spatial resolution, require contact, or produce diffuse activation. In the first aim, the team will stimulate cultured cells expressing mechanosensitive (PIEZO1/2) and thermosensitive (TRPV1-4) ion channels using pulsed light and record activation through calcium imaging, fluorescent activity dyes, and patch-clamp electrophysiology. In the second aim, the team will evaluate behavioral and cortical responses to photoacoustic stimulation in mice using widefield calcium imaging and vibratory stimuli as a benchmark. The work combines expertise in materials science, ion channel biology, and systems neuroscience across a co-located team at the University of Rochester. Performance occurs in New York. The period of performance runs through August 31, 2028. The research is expected to yield a scalable, non-invasive tool for high-resolution activation of somatosensory structures, enabling mechanotransduction studies and laying groundwork for future applications in haptic prosthetics and neuromodulation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.5k | 9/3/26 |