Project Grant R21EB039495
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $411,475 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to engineer a multiplexed biomaterial-based bioluminescent biosensor platform for real-time sepsis diagnosis and precision immunotherapy guidance. The recipient will develop a rapid ex vivo biosensor using biomaterial-immobilized complementation antibody pairs to dynamically sense proteomic...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Research Foundation For The State University Of New York $244,500 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and mechanistically characterize sulfonium-based lipid nanoparticles for mRNA and CRISPR/Cas9 delivery to the brain. The award funds research to elucidate how sulfonium-based lipid nanoparticles mediate...
- The National Institute of Biomedical Imaging and Bioengineering awarded $318,676 to Massachusetts General Hospital on February 13, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate a microfluidic chip technology for high-throughput loading of cryoprotective agents into therapeutic allogeneic immune cells. The project, titled VELCPA (Veloporation for CPA Loading), addresses cell cryopreservation...
- The National Institute of Dental and Craniofacial Research awarded the University of Rochester $415,813 on July 7, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a modular microphysiologic system (MPS) for culturing three-dimensional innervated salivary gland tissue mimetics in array format. The funded research will create a platform capable of static and optional perfused culture of organoids and tissues arranged in arrays, addressing a gap in current...
- The National Cancer Institute awarded the University of Rochester $814,967 on September 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to investigate trajectories of neurotoxicity among adolescents and young adults with Hodgkin lymphoma. The award funds research examining long-term neurotoxic effects of cancer therapy—including cancer-related cognitive impairment and peripheral and autonomic neuropathy—in this population despite the absence of central nervous...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Regents of the University of Minnesota $471,967 on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of dual density-dependent molecular AND gates—engineered targeting ligands that selectively bind cells expressing high levels of two distinct antigens via bispecific avidity. The research addresses on-target,...
- The National Institute of General Medical Sciences awarded the University of Rochester $578,733 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate the biological roles of tRNA modification enzymes. The award funds research combining biochemistry, molecular biology, and genetics to resolve knowledge gaps about how tRNA modifications impact tRNA structure and function, the roles of vertebrate-specific tRNA modification enzymes, and how these...
- The National Institute of Biomedical Imaging and Bioengineering awarded $182,558 to Iowa State University of Science and Technology on May 6, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a bioinspired drug discovery strategy for personalized combination immunoregulatory therapeutics. The research leverages the foreign body response within subcutaneous biomaterial scaffold implants to identify...
- The National Institute of Biomedical Imaging and Bioengineering awarded New York University $186,504 on July 3, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop continuous flow manufacturing processes for antibody-loaded nanoparticles as a non-opioid therapy for oral cancer pain. The award funds development of the Biologics Sequential Nanoprecipitation (BIOSNAP) process, a novel manufacturing method designed...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Rochester $145,400 on June 15, 2026, under the Research Infrastructure Programs (CFDA 93.351) to procure an ultrafine particle generator and scanning mobility particle sizer integrated system for the University of Rochester's Inhalation Exposure Facility. The system supports basic and translational research on how airborne substances, alone or combined with other...
The National Institute of Biomedical Imaging and Bioengineering awarded the University of Rochester $226,625 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a tandem-chip microphysiological system for assessing cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome in immunotherapy patients. The recipient will engineer an integrated drug development tool comprising an upstream silicon-membrane microphysiological system that models cytokine release syndrome using patient blood, coupled to a downstream cytokine-responsive neurovascular unit chip that recapitulates immune effector cell-associated neurotoxicity syndrome hallmarks. The system aims to enable mechanistic, patient-specific safety profiling to guide T cell-engaging bispecific antibody and chimeric antigen receptor T cell therapy development and support clinical decision-making. The platform has broader utility in understanding systemic inflammation-driven brain injury in sepsis, acute lung injury, and postoperative delirium. The work builds on established microphysiological systems technologies and integrated photonic biosensors developed at Rochester for blood-brain barrier modeling and real-time cytokine monitoring. Performance occurs at Rochester, New York. The period of performance runs through August 31, 2028. The assistance type is a Project Grant, a hypothesis-driven research award supporting discovery and applied research in biomedical imaging and bioengineering technologies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $226.6k | 8/20/26 |