Project Grant R21EY039508
- The National Eye Institute awarded The University of Texas Southwestern Medical Center $456,500 on July 1, 2026, under the Vision Research program (CFDA 93.867, Assistance Listing) for spatial molecular profiling of optic nerve injury and assessment of extracellular matrix (ECM) proteins. The research examines why regenerated retinal ganglion cell (RGC) axons fail to reach the brain after optic nerve injury, instead following circuitous pathways within fibrotic scars—a phenomenon the...
- The National Eye Institute awarded Baylor College of Medicine $1.6 million on September 30, 2025, under the Vision Research program (CFDA 93.867) to conduct basic research on Hippo and Wnt pathway regulation of mammalian Müller glial cell reprogramming and proliferation as a strategy for retinal regeneration in glaucoma, macular degeneration, diabetic retinopathy, and traumatic retinal injury. The research employs genetic loss- and gain-of-function experiments, fate mapping, and single-cell...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $2,271,828 to The University of Texas Southwestern Medical Center on September 1, 2026, under the Vision Research program (CFDA 93.867). The recipient will conduct research into the cellular and molecular mechanisms governing optic nerve myelin integrity, with emphasis on understanding how myelin whorls—multilayered degenerative myelin structures that appear in demyelinating...
- The National Eye Institute awarded Baylor College of Medicine $487,986 on September 1, 2026, under the Vision Research program (CFDA 93.867) to dissect retinal glial regulatory mechanisms and refine age-related macular degeneration risk loci through high-throughput functional genomics. The research applies innovative genomics approaches to test the hypothesis that retinal glial function is modulated by AMD risk variants in genes enriched within specific functional networks. The work addresses...
- The National Eye Institute awarded Baylor College of Medicine $120,902 on April 15, 2026, under the Vision Research program (CFDA 93.867) to support research into the molecular mechanisms and axon-glia interactions at the paranodal junction. The project addresses the gap in understanding paranodal junction biology through a medium-throughput pipeline combining proximity-biotinylation-based subdomain proteomic profiling, CRISPR/Cas9 genome editing, and cell type-specific AAV delivery systems. The...
- The National Eye Institute, a division of the Department of Health and Human Services National Institutes of Health, awarded $451,871 to the University of Texas at Austin on September 1, 2026, under the Vision Research program (CFDA 93.867, Assistance Listing program R01EY038362). The award funds research on anticipation and integration in the primate visual system, specifically investigating how temporal prediction shapes neural computation and visual representation. The project will test the...
- The National Eye Institute awarded The Methodist Hospital Research Institute $1,029,472 on May 1, 2026, under the Vision Research program (CFDA 93.867) to develop mitochondrial-based cell therapy for age-related macular degeneration. The recipient will create a sustainable source of mitochondria proximal to the retinal pigment epithelium using mesenchymal stem cells transfected with nuclear respiratory factor 1 (NRF1), a driver of mitochondrial biogenesis. The work aims to determine how NRF1...
- The National Eye Institute awarded Baylor College of Medicine $646,167 on April 1, 2026, for investigations of cellular and molecular mechanisms underlying age-related macular degeneration (AMD) under the Vision Research program (CFDA 93.867). The project applies high-throughput functional genomics approaches to test whether non-coding risk variants in AMD exert their effects through gene expression regulation enriched within specific functional networks in disease-relevant tissues. The work...
- The National Eye Institute, part of the National Institutes of Health within the Department of Health and Human Services, awarded Creighton University $350,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support discovery and development of novel trifunctional hybrid compounds for glaucoma therapy. The funded research focuses on designing and evaluating trifunctional hybrid compounds that integrate three disease-modifying entities—an FP...
- The National Eye Institute awarded the University of Pittsburgh $433,324 under the Vision Research program (CFDA 93.867) on September 1, 2026, to develop next-generation microfluidic platforms for high-throughput screening of axon growth-promoting compounds as potential regeneration therapies for glaucoma and optic neuropathies. The project focuses on addressing limitations in conventional axon growth assays by engineering microfluidic devices that enable defined chemoattractant gradients,...
The National Eye Institute awarded Texas A&M Agrilife Research $432,061 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop a rapid protein deletion platform for central nervous system neurons. The project will design and validate an innovative molecular genetic tool that enables rapid, reversible protein deletion in adult CNS neurons through controlled proteasomal degradation using antibody-based engineered protein degraders delivered intracellularly via endosomal escape peptides. The platform will employ these degraders to bind target proteins and recruit the ubiquitin-proteasome system to induce acute, tunable target degradation in less than an hour, providing temporal control of proteostasis and protein function. Aim 1 will optimize degrader design and delivery parameters in neuronal cultures. Aim 2 will validate the system's ability to delete key intracellular proteins in primary retinal ganglion cells by targeting known suppressors of axon regeneration in adult CNS neurons that act on distinct pathways, have different protein stabilities, and function in different intracellular compartments. The capability to rapidly delete proteins in neurons would enable studies into dynamic neural functions and processes and has significant translational potential for treating acute neurological perturbations such as traumatic injury. Performance occurs in College Station, Texas, with a period of performance from September 1, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $432.1k | 9/2/26 |