Project Grant R21EY038491
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Washington University a $1,001,009 Vision Research (CFDA 93.867) Project Grant effective July 1, 2025, with a completion date of March 31, 2030. This award funds fundamental research investigating how visual signals for eye fixation and optokinetic reflex (OKR)—a reflexive eye movement triggered by peripheral visual motion—interact within the retina. The research directly addresses a significant gap in understanding...
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $902,000 to the University of California, San Francisco for a two-year project (September 1, 2025 – August 31, 2027) to conduct multimodal characterization of a novel inherited mouse model of glaucoma. The primary deliverables include comprehensive phenotypic characterization of GLIS1 knockout mice across two genetic backgrounds, evaluating structural and functional...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded Northwestern University a $1.62 million Project Grant on September 1, 2025, to develop computational models and diagnostic tools for improving glaucoma treatment outcomes. The three-year project, extending through August 31, 2028, focuses on modeling aqueous humor outflow based on a digital twin of the anterior eye imaged by robotic optical coherence tomography (OCT). The...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $764,881 Project Grant to the University of Colorado-Denver on September 15, 2025, to investigate the role of advanced glycation end products (AGEs) in primary open angle glaucoma (POAG). Primary open angle glaucoma is the most common form of glaucoma, accounting for approximately 80% of all glaucoma cases globally and affecting 80 million people, with 11 million...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant of $545,948 under the Vision Research program (CFDA 93.867) to advance understanding of glaucoma pathophysiology. The award, effective April 1, 2026 through March 31, 2030, supports research investigating the role of reactive astrocytes in glaucoma progression and retinal ganglion cell (RGC) survival. The research aims to move beyond traditional neurocentric...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded Oregon Health & Science University a $598,108 Project Grant beginning September 1, 2025, with completion targeted for April 30, 2030. This multidisciplinary research initiative will develop innovative optical coherence tomography (OCT) imaging technologies and objective biomarkers to assess photoreceptor function and integrity in retinal disease. The project addresses a...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $421,136 Project Grant to the University of Maryland, College Park, effective August 1, 2025, through July 31, 2027, under the Vision Research program (CFDA 93.867). This award supports research into advanced wavefront shaping techniques designed to enable high-resolution fundus imaging in patients with ocular opacities—conditions affecting the cornea and lens that currently prevent effective posterior segment eye...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $493,642 to the National Opinion Research Center (NORC) under the Vision Research program (CFDA 93.867) beginning September 1, 2025, and concluding August 31, 2027. This project addresses vision and eye health disparities by developing systematic mechanisms to identify and analyze geographic clusters of vision and eye health problems using secondary surveillance data. The primary deliverables include: (1) development of...
- Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $417,162 to the University of Houston System for a two-year project (July 1, 2025 – June 30, 2027) investigating the birefringence properties of the lamina cribrosa and posterior eye structures as they relate to glaucoma detection and diagnosis. The project addresses a critical clinical need by developing advanced optical imaging methodologies to detect early structural and stress-related changes...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a three-year Project Grant totaling $2,674,763 to Centre Hospitalier De L'Université De Montréal (CHUM) beginning September 30, 2025, with completion targeted for September 29, 2028. This award funds research investigating interpericyte tunneling nanotubes (IPTNTs) as therapeutic targets for glaucoma treatment and vision restoration. The research will generate empirical findings...
The National Eye Institute (NEI) awarded $427,625 under the Vision Research program (CFDA 93.867) to The Washington University for a two-year project (April 1, 2026 – March 31, 2028) to develop novel statistical methodologies for detecting and characterizing visual field progression in primary open-angle glaucoma (POAG). The primary deliverables include: (1) a change-point statistical model integrating longitudinal mean deviation measures to identify early disease transitions and variability in visual field deterioration; (2) spatial-temporal modeling techniques to improve sensitivity in detecting localized visual field changes while accounting for spatial correlations across retinal locations; and (3) a user-friendly R software package to disseminate these methodologies for use by researchers and clinicians. The research leverages the Ocular Hypertension Treatment Study dataset to enhance early detection of POAG-related vision loss and optimize treatment strategies. Beyond glaucoma applications, the statistical methodologies developed through this award will have broad applicability for analyzing spatial-temporal data in other medical domains. The project directly addresses critical gaps in current diagnostic methods by improving the detection of early-stage disease transitions and refining estimates of differential progression rates, thereby facilitating the identification of high-risk individuals who require timely intervention to prevent vision loss.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 4/3/26 |