Project Grant R21EY038227
- The National Eye Institute awarded Massachusetts Eye and Ear Infirmary $467,277 on July 1, 2026, under the Vision Research program (CFDA 93.867) to develop and validate a clinical neuropsychological assessment battery combined with mobile eye tracking to characterize the visuoperceptual profile of cerebral visual impairment. The testing battery comprises five standardized neuropsychological assessments focused on evaluating visual scanning, planning, processing speed, and visuomotor...
- The National Eye Institute of the Department of Health and Human Services awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $723,931 on August 15, 2026, under the Vision Research program (CFDA 93.867). The award funds functional characterization of lateral geniculate nucleus (LGN) microstimulation as an advanced artificial vision system. The research validates a novel 1000-channel electrode array called the Fountain Probe, engineered for volumetric...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- The National Eye Institute awarded $753,787 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop low-cost ultra-widefield retinal optical coherence tomography (OCT) technology based on photonic-electronic integration. The project addresses cost barriers that limit clinical availability of OCT instrumentation used to detect and monitor diabetic retinopathy, age-related macular...
- Federal Project Grant Award Summary Award Overview Massachusetts General Hospital received a $453,750 Vision Research (CFDA 93.867) Project Grant from the National Eye Institute, effective September 1, 2025, through August 31, 2027. The award supports fundamental neuroscience research aimed at characterizing the cellular architecture and genetic organization of the lateral geniculate nucleus (LGN), a critical visual processing center in the brain. Research Products and Services The project...
- The National Eye Institute awarded Massachusetts Eye and Ear Infirmary $663,406 on April 1, 2026, under the Vision Research program (CFDA 93.867) to elucidate the molecular mechanisms of secondary cone degeneration in models of retinitis pigmentosa. The recipient will develop a novel AAV-based retinoic acid signaling activator and test whether it can improve photopic visual acuity in multiple mouse models of retinitis pigmentosa. The work will also aim to elucidate the molecular and cellular...
- The National Eye Institute awarded Tufts Medical Center Parent, Inc. $490,875 on August 1, 2026, under the Vision Research program (CFDA 93.867) to conduct genome-wide association studies on steroid-induced ocular hypertension and related glaucomas, with focus on the COL11A1 genetic locus and its role in trabecular meshwork and juxtacanalicular tissue fibrosis that impedes aqueous humor outflow. The research project examines how genomic variants in COL11A1, which encodes the alpha1 chain of type...
- The National Eye Institute awarded the President and Fellows of Harvard College $802,355 under the Vision Research program (CFDA 93.867) on May 1, 2026, to investigate experience-driven astrocytic glucocorticoid signaling as a regulator of visual plasticity in the developing visual cortex. The research characterizes how glucocorticoid receptor signaling within astrocytes of the primary visual cortex responds to sensory experience during postnatal development, driving gene expression, astrocyte...
- The National Eye Institute awarded The Schepens Eye Research Institute Inc. $506,030 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop an open-source solution for exporting and integrating optical coherence tomography data across institutions. The project addresses a critical barrier in ophthalmic research: OCT imaging data from multiple manufacturers is stored in over ten proprietary, undocumented formats with export tools that are prohibitively slow—exporting a...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $643,357 on June 15, 2026, under the Vision Research program (CFDA 93.867) to develop a Brillouin microscopy-based imaging method for direct, high-resolution measurement of corneal hydration. The project aims to create a combined Brillouin–optical coherence tomography system to map corneal...
The National Eye Institute awarded The General Hospital Corporation (Massachusetts General Hospital) $453,750 on September 1, 2026, under the Vision Research program (CFDA 93.867) to establish a stratified risk profile for cerebral visual impairment in infants. The project will utilize an existing clinical dataset to identify infant, maternal, and neurologic risk factors associated with cerebral visual impairment (CVI) diagnosis. The research will examine records from 400 patients with CVI and 2,000 controls without CVI but with similar underlying etiologies, applying elastic net regularized regression models to identify characteristics associated with increased risk for CVI and protective factors. Aim 1 will conduct descriptive data analysis and regression analysis to determine additive risk across infant, maternal, and neurologic factors. Aim 2A will evaluate the sensitivity of neuroimaging alone in identifying individuals with CVI, while Aim 2B will determine the additive predictive value of including neuroradiologic data in risk profiles. The project addresses a public health gap: although CVI is a leading cause of pediatric-onset visual impairment in the United States, routine clinical screening is not standard practice, leaving many at-risk children unidentified and without timely intervention. The period of performance runs from September 1, 2026, through August 31, 2028. Work is performed in Boston, Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $453.8k | 8/19/26 |