Project Grant R21EY037941
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $586,258 project grant to Wayne State University to characterize the role of eosinophils in modulating the corneal response to Pseudomonas aeruginosa-induced infection. The 4-year project, commencing on July 1, 2025 and completing on April 30, 2029, aims to investigate the spatiotemporal distribution, phenotypic profiles, and proteomic changes of eosinophils during corneal infection. The...
- This $428,152 Project Grant awarded by the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research at Wayne State University to investigate the role of the serine protease matriptase in corneal epithelial homeostasis and repair. The project aims to determine how matriptase promotes corneal epithelial barrier function and tissue repair through regulation of tight junctions and activation of the HGF/c-Met signaling pathway. The research will...
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $450,300 to support research aimed at understanding how corneal limbal stem cells function during wound healing. The project, being conducted by The Regents of the University of California, San Francisco (UCSF), seeks to advance the understanding of limbal stem cell populations and their role in maintaining corneal homeostasis and enabling corneal wound repair. This...
- This Project Grant award of $394,285, funded by the National Eye Institute (CFDA 93.867 - Vision Research), supports research at the University of Houston to develop decorin-based drugs for treating corneal scarring and neovascularization. The key objectives are to characterize the binding interfaces of decorin with TGF-β1 and VEGFR2 in order to engineer novel decorin mimetic drugs. This research aims to provide alternative treatment options for preventing corneal opacity and vision loss...
- The National Eye Institute (NEI) awarded a $451,000 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Regents of the University of California, San Francisco (UCSF) to conduct a multimodal characterization of a novel inherited mouse model of glaucoma. The research aims to evaluate structural and functional changes in the mouse model, including axonal degeneration, retinal ganglion cell loss, dendritic changes, and neuroinflammatory responses. It will also identify...
- This federal Project Grant award of $243,000 from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to understand the role of the protein SMAD4 in regulating the extracellular matrix homeostasis of the corneal stroma. The research aims to elucidate how SMAD4 controls both the synthesis and degradation of the corneal extracellular matrix, which is critical for corneal stromal morphogenesis and homeostasis. The project, led by researchers at the...
- The National Eye Institute (NEI) awarded a Project Grant of $433,125 to The Ohio State University (OSU) to investigate tissue factor (TF) as a potential biomarker and therapy for corneal neovascularization (CNV), a leading cause of blindness worldwide. The grant, under the NEI's Vision Research program (CFDA 93.867), aims to inhibit the growth of abnormal blood vessels in the cornea through targeting TF. The research efforts at OSU will explore TF's role in CNV and develop an immunoconjugate...
- This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) is supporting research at New York University (NYU) to investigate the mechanism of corneal lens development in the Drosophila model organism. The $142,749 award, spanning September 2025 to August 2027, aims to use genetic, microscopy, and transcriptomic approaches to study the role of the polysaccharide chitin and the central and lattice cells of the fly corneal lens in...
- The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $693,423 Project Grant on September 15, 2025 to the University of Mississippi Medical Center (UMMC) to develop a multivalent antibody cocktail for the treatment of bacterial endophthalmitis. The goal of this 1-year project is to translate prior research on ocular microbiology into a new drug that can be used in conjunction with antibiotics to combat damage and loss of retinal function caused by...
- The National Eye Institute awarded a $615,979 Project Grant to Wayne State University to investigate a peptide-based combination therapy for restoring structure and function in the diabetic cornea. The grant falls under the Vision Research federal grant program (CFDA 93.867), which supports research aimed at understanding, preventing, and treating vision-related conditions and diseases. The primary objectives of this 4-year project are to: 1) establish the therapeutic role of TB4 and VIP as a...
The National Eye Institute (NEI) awarded a $431,750 Project Grant to the University of Houston System to conduct research on the mechanisms of scarless corneal wound healing in Acomys cahirinus (African spiny mice) compared to Mus musculus (common house mice). The research, funded under the NEI's Vision Research program (CFDA 93.867), aims to establish whether the African spiny mice can regenerate corneal tissue without scarring following an alkali burn injury and to characterize the underlying cellular and molecular mechanisms. The project will run from September 30, 2025 to July 31, 2027. This research builds on the University of Houston System's expertise in vision science and regenerative biology, and is expected to provide insights that could advance treatments for corneal injuries and diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 9/23/25 |