Project Grant R21EY036999
Award Date
2/1/25
Completion Date
1/31/27
Dollars Obligated
$214K
Federal Agency
National Eye Institute
Awardee
Miami University (T6J6AF3AM8M8)
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Ohio, USA
Similar Awards
The National Eye Institute (NEI) awarded a $146,922 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Johns Hopkins University. The grant supports research to understand how transcription factors regulate chromatin structure and gene expression to control cell fate specification during mouse retinal development. Through single-cell Hi-C, the project aims to capture 3D chromatin interactions in mouse retinal cells at key developmental stages and identify changes...
This $413,741 Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will support research to investigate the genetic and epigenetic mechanisms underlying retinal development and differentiation. The research aims to provide a deeper understanding of the chromatin-based regulatory processes that govern retinal transcriptional programs and how disruptions in these core regulatory networks can lead to congenital vision disorders...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will support research to characterize the composition and function of Optix-cofactor transcription complexes in the development of the fly eye and brain. The $448,250 award, granted on May 1, 2025, will enable the Research Foundation for the State University of New York, through its Upstate Medical Center, to conduct investigations into how the transcription factor Optix...
The National Eye Institute (NEI) awarded a $249,000 Project Grant (CFDA 93.867 - Vision Research) to The Leland Stanford Junior University to study the molecular mechanisms regulating the expression of phototransduction genes in mammalian rod photoreceptors. The three-year research project, beginning on August 1, 2024, aims to investigate how transcriptional elongation and mRNA processing are coupled to enhance the efficiency and accuracy of gene expression, as defects in these processes can...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides USD 366,399 to the Trustees of Indiana University to fund research on the role of the PAX6 transcription factors in specifying and patterning the Drosophila (fruit fly) compound eye. The overarching goal is to understand how the earliest steps in eye formation are controlled, with a focus on the individual and combined contributions of the PAX6 genes Eyeless (Ey)...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $651,846 to The Johns Hopkins University to identify gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller glia. The research aims to determine the mechanisms by which key transcription factors regulate developmental competence, proliferation, and neurogenesis in retinal progenitor cells. Findings from this 5-year...
The National Eye Institute (NEI) awarded a $413,920 Project Grant (CFDA 93.867 - Vision Research) to the University of Northern Colorado (UNC) to develop new biophysical models of eye morphogenesis processes, including choroid fissure closure and foveal pit formation. The three-year project will create quantitative models to study the relationships between molecular regulation and mechanical forces that shape the developing vertebrate eye. Key project goals include illuminating the mechanisms...
This $1,789,542 Project Grant awarded by the National Eye Institute (NEI), Federal Grant Program 93.867 - Vision Research, will support research to identify and characterize modular super-enhancers that regulate the expression of key early retinal transcription factor genes during murine and human retinal development. The grant recipient, St. Jude Children's Research Hospital Inc., will use their extensive Integrated Retinal Nucleome Database (IRNDB v.2) to map promoter-super-enhancer...
The National Eye Institute (NEI) awarded a $210,899.12 Project Grant under the Vision Research program (CFDA 93.867) to The Johns Hopkins University. The award supports research to elucidate the gene regulatory networks that drive neural regeneration, with a focus on understanding the mechanisms that limit the ability of retinal pigment epithelium (RPE) cells to regenerate retinal neurons in vertebrates. The 1-year project will profile transcription factor activity and chromatin accessibility...
The National Eye Institute (NEI) awarded a $714,141 Project Grant (CFDA 93.867 - Vision Research) to the University of Utah to conduct research on the mechanisms of hedgehog signaling in vertebrate eye development. The project aims to: (1) investigate how the G protein coupling and PKA-binding pathways of the Smoothened (SMO) receptor regulate retinal development and ganglion cell differentiation using human retinal organoid models; (2) assess the impact of these SMO-dependent pathways on...