This $176,550 Project Grant awarded by the National Eye Institute (NEI) under CFDA Program 93.867 (Vision Research) supports research to optimize C-MET signaling to enhance corneal epithelial homeostasis. The project aims to determine if inhibiting negative regulation of the C-MET receptor can prolong its activity and accelerate corneal wound healing. The research will involve in vitro studies using immortalized human corneal epithelial cells and in vivo testing in murine corneal wound healing...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) aims to develop a novel mRNA-based gene therapy approach to treat inherited retinal dystrophies (IRDs). The $346,500 award, spanning September 2024 to September 2026, will support research to combine self-amplifying and self-splicing RNA technologies to improve the longevity, reduce the immunogenicity, and assess the potential in vivo side effects of this mRNA-mediated...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) aims to develop a novel high-resolution corneal imaging system. The project will investigate a speckle illumination holographic imaging approach that can capture 3D information over the width and depth of the cornea, while also providing polarization-sensitive data on corneal anisotropy. The $237,996 award, spanning February 2025 to January 2027, will fund the...
This $157,568 Project Grant award from the National Eye Institute (NEI) Vision Research program (CFDA 93.867) supports research to understand the neural mechanisms underlying visual encoding and behavior in the context of retinal degeneration. The award recipient, The Regents of the University of California, San Francisco (UCSF), will leverage a mouse model of selective cone degeneration to investigate the impact of cone loss on noise correlations between direction-selective retinal ganglion...
The National Eye Institute (NEI) awarded a $2,111,817 Project Grant (CFDA 93.867 - Vision Research) to the Rector & Visitors of the University of Virginia (UVA) to research methods for improving outcomes of corneal transplantation. The project aims to investigate how the protein MG53 can help mitigate inflammation, vascularization, and fibrosis associated with corneal transplants, as well as optimize a topical formulation of recombinant human MG53 (rHMG53) for sustained release. UVA has...
This federal Project Grant award of $674,963 from the National Eye Institute (NEI) under CFDA Program 93.867 (Vision Research) supports translational research to advance the development of filociclovir (FCV) for the safe and effective treatment of human adenovirus (HAdV) ocular infections, including epidemic keratoconjunctivitis (EKC). Key objectives are to finalize the eye drop formulation, complete IND-enabling GLP toxicology studies, and fulfill regulatory requirements to support an...
This $753,189 Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), aims to identify novel therapeutic targets for corneal epithelial defects. The research will reveal the differential roles of basal epithelial cells in the central cornea, limbus, and conjunctiva in corneal homeostasis and wound repair. Specifically, the study will 1) characterize the heterogeneity of ocular surface basal epithelial cells and the mechanisms...
The National Eye Institute (NEI) awarded a $243,000 Project Grant (CFDA 93.867 - Vision Research) to the University of Cincinnati for a 2-year research project to investigate the role of the SMAD4 gene as a key regulator of extracellular matrix homeostasis in the corneal stroma. The research aims to elucidate how SMAD4 controls both the synthesis and degradation of the corneal extracellular matrix, which is critical for proper corneal stromal morphogenesis and maintaining tissue homeostasis....
The federal Project Grant award R01EY036478, provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research at the University of California, Irvine (UC Irvine) to investigate the role of immune cells, specifically monocytes and neutrophils, in fungal keratitis. The $1,083,078 award, with a project period from September 30, 2024 to June 30, 2028, will fund research with three key aims: 1) Examining neutrophil activation and the effect of monocyte...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $1,817,520.00 in funding to the University of Washington to develop a non-contact, non-invasive clinical tool based on optical coherence tomography and elastography (OCE). The goal is to simultaneously map the geometry, curvature, thickness, and in-plane and out-of-plane mechanical moduli of the cornea for longitudinal pre- and post-operative diagnostics of keratoconus...