The National Eye Institute (NEI) awarded a $714,189 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the Rector & Visitors of the University of Virginia (UVA) to conduct research on "Targeting the Multicellular Process of Corneal Regeneration and Vascularization to Enhance Outcome of Cornea Transplantation." The project aims to investigate how the muscle-derived protein MG53 can improve the healing and regenerative capacity of corneal transplants, as well as mitigate inflammation and vascularization. UVA will collaborate with sub-awardees The Ohio State University and Chapman University to: 1) mechanistically characterize MG53's role in preserving corneal integrity and dampening inflammation/fibrosis associated with transplantation, and 2) optimize a gel-based formulation of recombinant human MG53 (rhMG53) for sustained topical release on the cornea. The project will run from June 2024 to March 2029 and aims to advance the understanding of how the multi-cellular functions of MG53 can enhance outcomes of corneal transplantation.
Generated 3/4/25, 7:27 AM