This federal Project Grant award of $364,324 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research at the University of Oregon to investigate how the microbiome impacts the development of the visual system. The key objectives are to: Test the hypothesis that normal visual system development depends on the sensing of specific secreted bacterial factors by certain cell types that mediate communication between the gut microbiome and the brain. Use a gnotobiotic zebrafish...
This $433,125 federal Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) to The Ohio State University will support research to characterize the function of delta-catenin and the structure of the tricellular adherens junctional complex in lens fiber cells. Specifically, the research aims to test the requirement of delta-catenin for lens function and identify the protein interactions within the tricellular adherens junction. This work will provide the first...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research to study how the neural architecture of the retina affects signal processing in the macaque retina. The $121,665 award, effective June 1, 2025 through November 30, 2027, will be used by the University of Wisconsin - Madison to investigate: How cellular connectivity in different retinal regions impacts the sensitivity of the rod visual pathway, which is...
This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, under the Vision Research (CFDA 93.867) program, provides $500,500 to support research on the role of retinal ganglion cells in shaping the identity and function of neurons in the superior colliculus visual processing region. The key objectives are to: 1) determine how retinal input influences the morphology and transcriptional profiles of genetically-defined neuron...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $476,451 in funding to The Trustees of Princeton University to conduct research on the development of the human dorsal visual cortex. The project aims to generate a functional and structural atlas of the dorsal visual stream across child, adolescent, and adult development, leveraging multimodal neuroimaging, quantitative MRI, and behavioral experiments. This...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to understand the chromatin architectural landscape of retinal development at the single-cell level. The $146,922 award, effective January 30, 2025 through May 31, 2025, aims to capture 3D chromatin interactions of mouse retinal cells at key developmental stages using a single-cell Hi-C (SCHI-C) approach. The research also seeks to identify changes in...
This $429,016 federal Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) to Oakland University supports research to identify the mechanisms by which a subset of retinal amacrine cells, called starburst amacrine cells, initiate and propagate spontaneous cholinergic waves in the developing retina. The objectives are to determine the distribution and properties of these cholinergic wave "pacemaker" cells (Aim 1) and to elucidate the calcium-dependent...
This federal Project Grant award of $477,109.00, provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research to determine how the transcriptional regulator PRDM13 regulates retinal development and its association with North Carolina macular dystrophy. The overarching goal is to further the understanding of mammalian retinal development by establishing the mechanisms by which PRDM13 guides cell fate decisions, and how these contribute to healthy...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $192,900 to support research at the Albert Einstein College of Medicine examining how locomotion affects the flow of visual information between brain areas. The goal is to understand how brain states, as influenced by locomotion, modulate sensory processing and inter-areal communication within the visual system. The research will utilize high-density neural...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to investigate the structural basis of selective inhibition toward gap junction channels involved in vision. The total funding amount is $153,512, awarded on February 13, 2025, with an ultimate completion date of June 30, 2027. The research aims to leverage recent advances in cryo-electron microscopy and fragment antigen-binding (Fab) technologies to elucidate the...