Federal Project Grant Award Summary

The University of Louisville's Office of Research & Innovation received a $425,987 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) to conduct research on cadmium-induced pulmonary arterial hypertension (PAH) pathogenesis and underlying mechanisms. The award, obligated on April 23, 2026, supports a two-year research project concluding April 22, 2028, and will be performed at the University of Louisville's Louisville, Kentucky facility.

This project contributes to NIEHS's mission to investigate how environmental exposures affect biological systems across the lifespan and translate findings into strategies to reduce disease burden and promote health. The research specifically addresses the increasing worldwide prevalence of PAH and its low five-year survival rate by examining the mechanisms through which cadmium—a heavy metal environmental contaminant—induces pulmonary arterial hypertension. The funded research falls within NIEHS's priority areas of investigating chemical environmental factors, understanding biological mechanisms of toxicity, and identifying evidence-based interventions to reduce exposure burden and improve population health outcomes.