This federal Project Grant award, provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, supports research to define the neurotoxic and neurodevelopmental health risks of per- and polyfluoroalkyl substances (PFAS). The $546,350 award, effective January 13, 2025 through October 31, 2029, aims to characterize the mechanisms by which PFAS affect brain development and function. Key objectives include defining PFAS uptake...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, supports research to further delineate the mitochondrial involvement in acute and chronic poisoning from organophosphates (OPs). The overarching goal is to investigate the mitochondrial contribution to neurological, cardiac and microcirculation sequelae, with a focus on novel biomarker development and therapy. The $821,373 award to The...
This $4,260,300 project grant from the National Institutes of Health's National Institute on Aging will fund research under the Aging Research program (CFDA 93.866) to investigate the association between in utero environmental exposures and life-course cognition and prodromal Alzheimer's disease in midlife. The Public Health Institute will leverage existing data and biospecimens from the 50+ year follow up of the Child Health and Development Studies birth cohort to conduct targeted and...
This federal Project Grant award of $756,318.00 from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health program (CFDA 93.113), will support research investigating the environmental health impacts of polyethoxylated surfactants. The research aims to comprehensively assess how these ubiquitous chemicals disrupt metabolic health, particularly their potential to promote unhealthy visceral adipose expansion through thyroid hormone receptor antagonism....
The University of California, Davis has been awarded a $423,657 Project Grant (CFDA 93.113 - Environmental Health) from the National Institute of Environmental Health Sciences (NIEHS) to study the impact of neonatal exposure to per- and polyfluoroalkyl substances (PFAS) on the microbiota-gut-brain axis. The research aims to determine if neonatal PFOA exposure leads to long-term deficits in the microbiota-gut-brain axis, including impacts on gut physiology and behavior, as well as whether...
This $776,150.33 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to examine the relationships between exposure to the antimicrobial and endocrine disrupting compound triclosan, pubertal hormones, the adolescent gut microbiome, and neurobehavior. The primary awardee, the University of Massachusetts, will leverage a longitudinal birth cohort study to profile the adolescent gut...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, will fund research at Wayne State University to investigate how exposure to per- and polyfluoroalkyl substances (PFAS) impacts placental health and susceptibility to infection-mediated preterm birth. The $1,651,801 award, effective September 5, 2024 through June 30, 2029, will allow the principal investigator, Dr. Petriello, to study how PFAS...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $3,727,176 to the University of North Carolina at Chapel Hill to study how environmental toxicants impact the development of TDP-43 proteinopathies, a hallmark of neurodegenerative disorders like frontotemporal dementia and amyotrophic lateral sclerosis. The research team will conduct in vivo and neuronal model experiments to evaluate the pathophysiological relevance of toxicant exposure,...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, provides $159,200.00 to the University of California, San Diego (UCSD) to conduct research on the role of oxidation-reduction (redox) signaling in normal neurodevelopment and the sensitivity of developing neurons to environmental exposures that can induce oxidative stress. The research aims to characterize redox signaling during...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, provides $391,640 to Swarthmore College to conduct research on organophosphorus pesticide bioactivation and detoxification using a planarian invertebrate model. The overarching goal is to establish planarians as a cost-effective rapid screening model for studying the mechanisms of developmental neurotoxicity caused by chronic...
This Project Grant award, provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program, aims to investigate the impact of exposure to organophosphate flame retardants (OPFRs) on metabolic and brain aging. The total funding amount is $409,508, with the award period running from September 16, 2024 to August 31, 2026.
The key products and services to be delivered under this grant include:
Defining the extent to which OPFR exposure, specifically triphenyl phosphate (TPHP), contributes to metabolic and cognitive decline in an aging mouse model. This will involve assessing the fecal microbiome, metabolome, in vivo metabolic and cognitive function, and senescence phenotypes in the colon, liver, and brain.
Mechanistically testing the causality of dysbiotic microbiota induced by TPHP exposure in exacerbating metabolic and brain aging via fecal microbiota transplantation experiments.
Providing evidence for TPHP as a new determinant in the exposome that drives gut dysbiosis, epithelial cell dysfunction, and a pro-inflammatory state leading to accelerated senescence.