This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, is providing $728,408 to investigate genetic factors that influence susceptibility to pesticide-induced Parkinson's disease. The research aims to biologically validate novel candidate gene variants identified through prior epidemiological studies. The project involves two complementary research approaches: 1) evaluating the effects...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, will fund research to investigate the potential impacts of developmental exposure to pyrethroid pesticides on neurodevelopmental disorders (NDDs) using the prairie vole as an animal model. The $605,550 award, effective May 1, 2025 through February 28, 2030, will support the University of Toledo in conducting a comprehensive...
This federal Project Grant award of $795,848 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program will support research at the University of California, Davis (UC Davis) to examine the impacts of prenatal wildfire smoke exposure on maternal immune function, epigenetic changes in children, and subsequent child neurodevelopmental and behavioral outcomes. The research aims to elucidate the immunologic and epigenetic pathways...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $164,561.00 to the University of California, Davis (UC Davis) to study the potential mediating role of cytokines and DNA methylation in the association between prenatal exposure to endocrine disrupting chemicals (EDCs) and the development of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in children. The research aims to:...
This federal Project Grant award, provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, supports research to define the neurotoxic and neurodevelopmental health risks of per- and polyfluoroalkyl substances (PFAS). The $546,350 award, effective January 13, 2025 through October 31, 2029, aims to characterize the mechanisms by which PFAS affect brain development and function. Key objectives include defining PFAS uptake...
The National Institutes of Health National Institute of Environmental Health Sciences awarded a $924,612 Project Grant to the California State University, East Bay Foundation, Inc. under the Environmental Health (CFDA 93.113) federal grant program. The grant will fund research from August 2022 to July 2025 to advance chemical risk assessment and predictive toxicology through the development, validation and integration of high-throughput mechanistic in vitro assays. Specifically, the grantee will...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $704,695 to The Roskamp Institute, Inc. to investigate the neurological effects of aerosolized red tide neurotoxins. The primary goals are to determine the dose-response relationship between aerosolized exposure to the neurotoxin brevetoxin and the development of neurological symptoms, as well as whether individuals with preexisting...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $431,750 Project Grant under the Environmental Health (CFDA 93.113) federal grant program to the University of California, Irvine (UCI). The 2-year grant, awarded on January 9, 2025, will support research to investigate a new signaling mechanism that triggers an innate immune response specifically after DNA damage blocks transcription. The study aims to determine how environmental agents that suppress transcription through...
This Project Grant award of $749,901, funded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, aims to elucidate the origins of the mutational landscape in cancer. The research project will integrate cellular DNA adductomics, nanopore sequencing, and single-molecule duplex sequencing to investigate how exposure to environmental mutagens, such as 1,2,3-trichloropropane, bromochloroacetic acid, and furan, contributes to the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, San Francisco (UCSF) provides $1,682,833 to study human-specific vulnerabilities and compensatory adaptations to age-related stressors in midbrain dopaminergic neurons. The primary goals are to: Measure dynamic gene regulatory responses and candidate protective pathways to age-related oxidative stress in human, chimpanzee, and rhesus macaque dopaminergic neurons using...