This Project Grant award, identified as R21ES036419, was provided by the National Institutes of Health (NIH) through the Trans-NIH Research Support program (CFDA 93.310). The grant, totaling $235,500, aims to investigate the use of electrophilic fatty acids (EFAs) as potential medical countermeasures to mitigate lung injury caused by chlorine (Cl2) exposure. The research, conducted by Rutgers, The State University of New Jersey, will focus on two key objectives: 1) Pre-screening up to 55 EFA compounds to identify the most effective inhibitors of pro-inflammatory macrophage activation, and 2) Examining the ability of five lead EFA compounds, each with structural modifications, to inhibit macrophage recruitment and alleviate Cl2-induced lung injury when administered intraperitoneally. The project will yield insights into the role of macrophage activation in Cl2 toxicity and the potential of EFAs as medical countermeasures against Cl2-induced lung damage. The award period runs from June 6, 2025, through May 31, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $235.5k | 6/6/25 |