Project Grant R21EB040046
- The National Institute of Biomedical Imaging and Bioengineering awarded the Regents of the University of Michigan $184,468 on August 19, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate a magnetic resonance imaging technique for measuring water velocity distribution in brain tissue. The project addresses impaired glymphatic clearance in neurodegenerative diseases including Alzheimer's,...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The Research Foundation For The State University Of New York $196,520 on May 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant R21NS149017). The award funds development and feasibility testing of a wearable, adhesive ultrasound patch for continuous monitoring of...
- The National Institute of Biomedical Imaging and Bioengineering awarded Rensselaer Polytechnic Institute $366,006 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a simulation-based inference framework that transforms functional near-infrared spectroscopy (fNIRS) data analysis through artificial intelligence. The project delivers a biophysically detailed simulator integrating realistic models...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Research Foundation For The State University Of New York $244,500 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and mechanistically characterize sulfonium-based lipid nanoparticles for mRNA and CRISPR/Cas9 delivery to the brain. The award funds research to elucidate how sulfonium-based lipid nanoparticles mediate...
- The National Institute of General Medical Sciences awarded The Research Foundation For The State University Of New York, operating as Stony Brook University, $1,367,189 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a high-speed atomic force microscope-infrared (HS-AFM-IR) instrument for real-time, label-free imaging of biomacromolecule dynamics in aqueous environments. The project will integrate atomic force microscopy with infrared imaging...
- The National Institute of Biomedical Imaging and Bioengineering awarded New York University School of Medicine $114,562 on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate a novel diffusion MRI framework for prostate cancer imaging. The recipient will develop a fast, high-resolution, distortion-free diffusion-weighted imaging protocol for the prostate that overcomes limitations in current...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Research Foundation of The City University of New York $151,168 on September 5, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop machine learning-enhanced molecular modeling of near-infrared fluorescent materials for bioimaging applications. The project addresses limitations in current near-infrared fluorescent probes used for surgical...
- The National Institute of Biomedical Imaging and Bioengineering awarded Sloan-Kettering Institute for Cancer Research $636,110 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop motion-tolerant pediatric MRI technology that reduces anesthesia dependence in tumor imaging. The funded research develops deep learning reconstruction techniques combined with radial k-space acquisition to compensate for...
- The National Institute of Biomedical Imaging and Bioengineering awarded Weill Medical College of Cornell University $678,471 on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a compact, portable transcranial Doppler ultrasound device for automated embolus detection in at-risk stroke patients. The funded work addresses the clinical gap in long-term, automated embolus monitoring outside clinical...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of North Carolina at Chapel Hill $610,678 on July 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop two innovative short echo-time magnetic resonance imaging technologies for advanced functional MRI applications. The recipient will develop, optimize, and benchmark SORDINO (steady-state on-the-ramp detection of...
The National Institute of Biomedical Imaging and Bioengineering awarded The Research Foundation For The State University Of New York (operating as Stony Brook University) $194,819 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate a noninvasive imaging framework that integrates fast tagging MRI with deep-learning based pattern recognition to quantify low-frequency cerebrospinal fluid oscillations in the human brain. The project addresses the technical challenge of detecting cerebrospinal fluid pulsations that support brain health through glymphatic clearance of metabolic waste. Conventional phase-contrast MRI suffers from phase instabilities that obscure low-frequency oscillations driven by cerebral vasomotion. The recipient will leverage balanced steady-state free precession (BSSFP) stop-bands—appearing as dark tags in MRI images—that integrate cerebrospinal fluid motion over approximately two seconds rather than instantaneous velocity, making them well suited for low-frequency oscillation detection. The project includes three specific aims: increasing BSSFP temporal resolution fivefold via golden-angle radial trajectory and sparsity-promoting reconstruction; adapting a vision transformer to separate low-frequency cerebrospinal fluid oscillations from cardiac and respiratory pulsations while accommodating inter-subject variation; and establishing reliability through a test-retest study and translational validation using an oscillation-modulation paradigm combining deep breathing and caffeine administration. Performance occurs in Stony Brook, New York. The project period runs from August 15, 2026, through June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $194.8k | 8/7/26 |