Project Grant R21EB038760
- The National Heart, Lung, and Blood Institute awarded $775,114 to the Research Institute At Nationwide Children's Hospital on June 12, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct preclinical evaluation of a cell-free tissue-engineered vascular graft designed for congenital heart surgery. The research addresses complications arising from prosthetic biomaterials currently used in surgical repair of complex congenital cardiac anomalies, including thromboembolic...
- The National Institute of Biomedical Imaging and Bioengineering awarded George Mason University $265,018 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a disposable wearable ultrasound patch for real-time, noninvasive monitoring of cardiac output and blood pressure in neonates and infants following cardiac surgery. The project addresses the absence of continuous hemodynamic monitoring solutions...
- The National Heart, Lung, and Blood Institute awarded the University of Wisconsin - Madison a Project Grant of $661,286 on July 22, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds development of a combined fetal magnetocardiography and echocardiography platform using optically-pumped magnetometer quantum sensors to enable simultaneous assessment of fetal cardiac electrical rhythm and structural function. Current prenatal diagnostic methods rely heavily...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Children's Hospital Corporation (Boston Children's Hospital) $267,000 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and expand the Fetal and Neonatal Development Imaging (FEDI) open-source software platform for analyzing early brain development via magnetic resonance imaging. The project addresses a critical gap in...
- The National Heart, Lung, and Blood Institute awarded New Jersey Institute of Technology $718,678 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop cardiac energy harvesting technology for leadless intracardiac pacemakers. The project addresses the clinical limitation that leadless pacemakers, used to treat heart block and ventricular dysrhythmias, suffer short battery life with over 40% failing within three years—a significant mismatch against...
- The National Institute of Child Health and Human Development awarded The Washington University $396,259 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and validate uterine peristalsis imaging (UPI), a noninvasive diagnostic technology that provides objective, quantitative measurements of uterine peristalsis to predict frozen embryo transfer outcomes. Approximately 200,000 patients undergo frozen embryo transfer annually...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $174,621 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop cardiac magnetic resonance imaging (CMR) techniques for monitoring congenital heart disease using ultra-low field (ULF) MRI systems. The recipient will adapt CMR to an inexpensive, unshielded, open-geometry ULF MRI system and apply machine learning techniques to mitigate hardware limitations and...
- The National Heart, Lung, and Blood Institute awarded the Research Institute At Nationwide Children's Hospital $3.147 million on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop surgical strategies improving long-term outcomes after Fontan surgery in children with single ventricle disease. The project addresses the long-term complications of the Fontan operation, a palliative surgical procedure that remains the standard of care for single ventricle...
- The National Heart, Lung, and Blood Institute awarded Research Institute At Nationwide Children's Hospital $1,326,945 on September 10, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a translatable molecular imaging paradigm for comprehensive assessment of peripheral artery disease (PAD). The recipient will characterize stages of peripheral atherosclerosis using dual-phase PET/CT imaging with fluorine-18 sodium fluoride (18F-NAF) to quantify both regional muscle...
- The National Heart, Lung, and Blood Institute awarded Worcester Polytechnic Institute $759,243 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop personalized computational and in vitro flow models of the fetal aorta and evaluate novel hemodynamic metrics for improved prenatal diagnosis of fetal coarctation of the aorta (COA). The project addresses limitations in contemporary prenatal imaging-based screening for COA, a congenital heart defect affecting...
The National Institute of Biomedical Imaging and Bioengineering awarded the Research Institute At Nationwide Children's Hospital $232,465 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to design and develop a percutaneous fetal pacemaker delivery system for treating congenital complete heart block in utero. The recipient will design a needle-based system with direct visualization capability to place a wireless pacemaker receiver on the epicardial surface of the fetal heart by crossing through the maternal abdomen, uterus, and fetal chest wall. The work includes miniaturizing imaging technology to enable fetal applications through an 18-gauge needle, with an embedded light source encapsulated to withstand wet environments. The recipient will evaluate the tool to deliver a mock wireless cardiac resynchronization therapy pacemaker receiver electrode in a fetal simulator and demonstrate feasibility in a pregnant sheep animal model. This approach aims to enable stable cardiac pacing directly to the fetus, allowing longer fetal growth in utero and reducing morbidity and mortality associated with premature delivery, which is the current standard treatment for congenital complete heart block with insufficient ventricular escape rate. Performance occurs in Columbus, Ohio. The award period runs through August 31, 2028. The assistance type is a Project Grant, which supports hypothesis- and design-driven research for biomedical imaging and bioengineering technologies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $232.5k | 8/18/26 |