Project Grant R01HL181427
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,349,491 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) to the University of North Carolina at Chapel Hill for research on cardiac pacemaking mechanisms, with performance extending from July 15, 2025 through April 30, 2029. The project investigates an "outside-in" model of cardiac pacemaking termed Extracellular Mediated Automaticity (EMA), which examines how extracellular...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded George Washington University a $664,432 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to develop wireless implantable cardiac systems for continuous multiparametric investigation of cardiac arrhythmias in vivo. The award, effective September 1, 2025, through May 31, 2029, supports the creation of an advanced biomedical device platform comprising a soft implantable probe,...
- Federal Project Grant Award Summary Northwestern University received a $696,259 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 1, 2026, through April 30, 2031. The award supports research integrating flexible electronics and optogenetics to enable real-time arrhythmic profiling of engineered heart tissues (EHTs). The project addresses current limitations in assessing cardiac arrhythmias...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of California, San Francisco a $556,295 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) effective August 1, 2025, with completion scheduled for May 31, 2030. This award supports research to advance understanding of cardiac pacemaking physiology and sinus node dysfunction (SND) through investigation of specialized pacemaker cell subpopulations. The...
- Federal Project Grant Award Summary Worcester Polytechnic Institute received a $232,500 project grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 15, 2025, with completion targeted for August 31, 2027. The project, titled "PACE-VT: A Non-Invasive, Machine-Learning-Driven Digital Twin Approach for Precise Targeting of Ventricular Tachycardia in Cardiac Stereotactic Body...
- Federal Grant Award Summary Michigan Technological University received a $589,998 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2028. The award supports research investigating cardiac sensory and sympathetic nerve dysregulation in hypertrophic cardiomyopathy (HCM), a genetic heart disease affecting approximately 1 in 500 individuals and representing the...
- Federal Project Grant Award Summary Massachusetts Institute of Technology received a $397,034 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion scheduled for July 31, 2027. The grant supports development of a transcatheter manufacturing toolkit for creating patient-specific, minimally-invasive left atrial appendage occlusion (LAAO) devices to prevent stroke in...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of California, Irvine a $350,112 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to develop phototransducer biomaterials for cardiac tissue stimulation. The research, which commenced August 1, 2025, and concludes July 31, 2027, focuses on designing nanostructured peptide assemblies that generate localized electrical charges upon light exposure at the cell-material interface. The project...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a $426,250 Project Grant effective April 1, 2026 through March 31, 2028 under the Cardiovascular Diseases Research program (CFDA 93.837) to develop cardiac organoids with deliberate cellular heterogeneity for modeling sinus node dysfunction (SND). The project will deliver a rigorous research platform utilizing human cardiac pacemaker organoids derived from induced...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Texas at Austin a $1,356,922 Project Grant on August 5, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop optimized novel leaflet biomaterials for replacement heart valves. Current bioprosthetic heart valves, which have remained largely unchanged since their development in 1971, suffer from limited durability due to mineralization and mechanical...
Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded New Jersey Institute of Technology (NJIT) a Project Grant totaling $718,678 under the Cardiovascular Diseases Research program (CFDA 93.837) beginning June 1, 2026, with a completion date of February 28, 2031. The project will develop an innovative cardiac energy harvesting (EH) strategy to extend the operational life of leadless intracardiac pacemakers. Specifically, NJIT will design advanced nanomaterials and bistable structures that integrate piezoelectric energy harvesting technology into existing leadless pacemaker designs. The technology will convert cardiac vibrational motions during the heart's diastole and systole into micro-watts of electrical power to recharge pacemaker batteries, thereby addressing the critical limitation of current devices that fail within three years despite patients living an average of 15+ years post-implantation. This clinical translational project directly supports the NHLBI's mission to foster heart and vascular research in basic, translational, and clinical sciences. By developing a self-sustainable energy solution that utilizes the unused internal spaces within leadless pacemakers, the award aims to eliminate complications associated with external energy harvesting devices that currently require additional thoracotomy procedures. Upon successful completion, the deliverable will be an integrated piezoelectric energy harvesting system capable of seamlessly functioning within current leadless pacemaker technology, thereby significantly improving device longevity and patient quality of life.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $718.7k | 6/1/26 |