Project Grant R21EB036709
- The National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, awarded a $363,480 Project Grant to the University of Texas at Dallas (UTD) to conduct research on engineering platelets for therapeutic applications. The 5-year project aims to (1) perform fundamental studies to understand how platelets interact with and internalize different synthetic materials, and (2) develop materials-based tools for engineering platelets...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $1,332,516.00 to the University of Texas at Austin to develop synthetic cells that mimic the essential functions of biological platelets. The project aims to create light-responsive, programmable synthetic cells that can undergo shape transformations, biochemical secretion, and mechanical adhesion to promote blood clotting, addressing the shortage of donor platelets used...
- This Project Grant award of $234,000.00 was provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to the University of Colorado-Denver to develop "hemostatic red blood cells" (T-RBCs) that can bind to collagen and fibrin to enhance clot formation and stability. The goal is to create a novel technology to address severe, non-compressible bleeding, which is a major cause of mortality worldwide, especially in low-resource settings. The...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Limax Biosciences Inc. aims to develop a new hemostatic hydrogel for advanced bleeding control. The project, which runs from October 1, 2025 to September 30, 2026, focuses on optimizing the "HemoMax" hydrogel to achieve rapid and effective adhesion on wet tissue surfaces, even in the presence of blood. This innovative biomaterial technology has the...
- This federal Project Grant award, provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop novel, synthetic therapies for stabilizing trauma victims in the critical "golden hour" after injury. The $1,087,534.00 grant, awarded to the University of Washington on March 1, 2025, with a completion date of January 31, 2029, has two...
- This $395,695 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop novel multi-modal ultrasound imaging methods to serve as predictive markers of tissue healing and non-invasively monitor tissue healing response. The project, conducted by the Texas A&M Engineering Experiment Station (Tees), seeks to...
- This Project Grant award of $829,406 from the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) supports research by the Texas A&M Engineering Experiment Station (Tees) on "Platelet Pathophysiology in Resistance to Antiangiogenic Therapy Against Ovarian Cancer Evaluated in a Vascularized TME-Chip". The 4-year project, running from August 2024 to July 2028, will investigate the role of platelets in the tumor microenvironment and resistance to...
- This federal Project Grant award of $944,676 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports the development of a novel platelet-inspired nanotechnology called Synthoplate (SP) by Haima Therapeutics LLC, a woman-owned small business in Cleveland, Ohio. The project aims to create a donor-independent therapeutic that can effectively restore hemostatic function in patients with traumatic brain injury who are taking antiplatelet agents,...
- The Department of Defense's Military Medical Research and Development program (CFDA 12.420) has awarded a $7,693,599 project grant to the University of Texas Health Science Center at Houston (UTHealth). The award, with a period of performance from Sep 15, 2023 to Sep 14, 2027, will fund research to study "Trauma-Induced Coagulopathy and the Blood-Brain Barrier: Impact of Resuscitation." As the prime grantee, UTHealth will leverage its expertise in biomedical research, clinical...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,031,644 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to Trustees of Tufts College, doing business as Trustee of Tufts College. The 4-year grant, awarded on February 1, 2025, supports research and development of advanced biomedical technologies to enable patient-centric microsampling and transport of dried blood or...
The University of Texas at Dallas received a $621,980.00 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The objective of this 3-year project is to develop a hemostatic agent in the form of sliding hydrogel-based microparticles, or "synthetic platelets", that can be systemically administered to trauma patients to rapidly arrest life-threatening hemorrhages. The research aims to replicate the adhesion and shape-changing behaviors of natural platelets to promote clot formation and stabilization at sites of vascular injury. Key deliverables include fabricating the sliding microgels with injury-targeting and shape-changing capabilities, and assessing their hemostatic efficacy through in vitro and in vivo testing. This project is part of NIBIB's broader mission to transform the understanding and treatment of disease through technological innovations in biomedical imaging and bioengineering.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $622.0k | 8/8/25 |