This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is providing $1,337,953.41 to the University of Arizona to develop and disseminate an advanced 2-photon Bessel beam light sheet (2PBLS) microscopy instrument for high-speed, sub-micron resolution volumetric imaging in deep tissue. The proposed instrument will enable faster...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $398,342 to the University of California, Davis to develop a novel miniature two-photon microscope that can simultaneously perform calcium imaging and optogenetic manipulation of neural activity in freely behaving mice. The device will integrate advanced optical and...
The National Institute of General Medical Sciences (NIGMS) awarded a $290,536 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Trestle Optics LLC, a small disadvantaged business, to develop a novel high numerical aperture catadioptric lens for ultra-broadband multimodal microscopy. This lens will enable advancements in existing nonlinear optical imaging modalities, such as three-photon excited fluorescence and third-harmonic generation, by overcoming limitations of...
This $1,302,368 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will establish a National Center for Biomedical Imaging and Bioengineering at the University of Michigan. The center will develop microsystems-based technologies for advanced fiber-coupled microendoscopes, including miniature scanners, actuators, and sensors to...
The National Institute of General Medical Sciences (NIGMS) awarded a $952,862 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Rochester to develop flexible, multi-wavelength fiber sources for nonlinear and multimodal imaging. The goal is to create robust, synchronized picosecond and femtosecond pulse sources that can significantly enhance imaging contrast and depth for biomedical research and clinical applications. The research program consists of...
This $305,000 National Science Foundation (NSF) SBIR Phase I project grant, awarded on March 1, 2025, aims to develop a compact, multi-color super-resolution imaging system capable of visualizing molecular structures in thick biological tissues with nanoscale precision. The project addresses limitations of existing imaging technologies by incorporating advanced features such as adaptive optics and spinning disk technology to minimize optical aberrations and scattering. The research objectives...
The University of Arizona received a $560,770 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant, awarded on May 1, 2025 with an end date of April 30, 2028, will support the development of a novel 3D-printed glass micro-optical system for biomedical and clinical imaging applications. Key objectives include building a...
This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP, CFDA 93.351) will provide $1,386,474 to Baylor College of Medicine to acquire a Femtonics ATLAS microscope system. The ATLAS microscope combines two-photon excitation with acousto-optical deflector scanning, enabling rapid, high-resolution 3D imaging of neuronal activity using fluorescent reporters. This state-of-the-art imaging system will support a diverse portfolio of...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,295,800 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a novel optical endoscope that does not require mechanical rotation to perform 360-degree in vivo imaging. The project aims to design and fabricate a metasurface that can...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $502,841 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to The Regents of the University of California, operating as Lawrence Berkeley National Laboratory (LBNL). The funding will support research and development of a novel detector readout concept for monolithic scintillation detectors that enables direct digitization...