Project Grant R21DK143430
- This $810,330 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program, to The Regents of the University of California, San Francisco (UCSF). The grant aims to leverage electronic health record data to understand how provider communication about kidney replacement therapy (KRT) options, such as home dialysis and kidney transplantation, may vary across...
- This Project Grant award of $860,513, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a detailed analysis of the long-term health outcomes of living kidney donors (LKDs) at New York University (NYU). The key objectives are to: 1) Examine the natural history of kidney function, albuminuria, and systolic blood pressure in LKDs, adjusting for variables...
- This $248,492 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports the development of a "Hydrogen Sulfide Delivery Technology for Organ Preservation Therapy" by Exhalix, LLC, a for-profit company based in Albuquerque, New Mexico. The project aims to address the significant shortage of viable donor kidneys for transplantation by developing a technology...
- This $2,833,514 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "Renal Metabolism in AKI", will fund research to investigate changes in kidney metabolism in sepsis-associated acute kidney injury (AKI) and their impact on kidney tubule injury and recovery. The University of California, San Diego (UCSD) is the awardee...
- This federal Project Grant award of $2,390,830 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) aims to develop scalable and transplantable pancreatic islet organoids with engineered oxygenation. The 4-year project, awarded on September 1, 2025, will be carried out by the University of California, San Francisco. The research seeks to create an islet-supportive microenvironment to improve islet engraftment efficiency for Type 1 diabetes patients undergoing...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on developing novel bioengineered regenerative medicine solutions based on vasculogenic regenerative medicine technology. The $543,826 award, granted on December 10, 2024, aims to investigate the mechanisms underlying in vivo vasculogenic reprogramming, specifically examining...
- This Project Grant award from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) totaling $715,110.00 aims to develop and optimize a novel "nano-RBC" blood substitute prototype. The key products and services to be delivered include: The project will use computational studies, synthetic and biological experiments to design a "smart" oxygen-delivery biomaterial with physiological oxygen binding/dissociation properties,...
- This federal Project Grant award of $3,010,432 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to develop mitoprotective therapies for the treatment of acute kidney injury (AKI). The key objectives of this research are to characterize a novel mitochondrial protein target, phospholipid scramblase 3 (PLSCR3), and evaluate pharmacological activators...
- This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...
- This $229,553 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund a 2-year mixed methods research study at the University of California, Irvine to investigate non-clinical factors that impact post-donation follow-up care for living kidney donors. The study aims to understand how donor characteristics like education, income, insurance status, and geographic location...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $423,017 to investigate the use of Lumbricus terrestris erythrocruorin (LTEC), a novel red blood cell substitute, for extending the duration of normothermic ex vivo kidney perfusion (NEVKP). The goal is to develop LTEC as an oxygen carrier to improve the viability and function of kidneys maintained outside the body, which would enhance kidney disease research by enabling longer preservation times. The 2-year project, awarded to The Regents of the University of California, San Francisco, aims to leverage LTEC's favorable properties, such as molecular stability and lack of nitric oxide scavenging, to overcome challenges with current NEVKP systems that are limited to 24-hour perfusion durations due to the damaging effects of red blood cell degradation products.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.0k | 9/10/25 |