Project Grant R21DK143406
- This Project Grant award, titled "Revolutionizing Renal Histopathology: Integrating Multiplexed Immunofluorescence and ML/AI Image-Based Biomarkers for Precision Diagnosis and Patient Stratification", is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $464,750 award aims to develop an advanced imaging and analysis platform for renal diagnostics,...
- This Project Grant award of $306,873 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to develop an AI-driven automated system for accurately generating Banff lesion scores from kidney biopsy slides. The project, titled "BANFF-AID: BANFF Automated Nephrology Feature Framework - Artificial Intelligence Diagnosis", will create custom AI models to extract...
- This Project Grant award for $194,380, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to study the role of the protein LIM-nebulette in maintaining the structural integrity of podocytes, which are specialized kidney cells. The research project, conducted by the Icahn School of Medicine at Mount Sinai, will utilize a novel mechanical stretch platform and...
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- This Project Grant award of $404,883 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop integrated spatial transcriptomics and proteomics technologies for studying kidney disease. The project, titled "Submicron-Resolution Integrated Spatial Transcriptomics and Proteomics for Studying Kidney Disease", will optimize a high-resolution spatial...
- This Project Grant award for $124,284 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research conducted by Weill Medical College of Cornell University. The key objectives are to: Develop a super-resolution deep learning framework to generate high-resolution 3D MRI volumes for enhanced monitoring of Autosomal Dominant Polycystic Kidney Disease (ADPKD), incorporating multiple...
- This federal Project Grant award of $155,011 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting research to develop a deep learning model combining magnetic resonance (MAG3) renal scans and kidney ultrasound imaging data to more accurately diagnose unilateral ureteropelvic junction obstruction (UPJO) in children with antenatal hydronephrosis. The research...
- This federal Project Grant award, in the amount of $531,999.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award is supporting research focused on understanding the role of alternative splicing in the proximal tubules of the kidney and its relationship to the progression of diabetic kidney disease. The research will investigate how diabetes...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $199,999 to the University of Florida to develop innovative artificial intelligence (AI)-based methods to support the discovery of potent, orally available small-molecule heparanase inhibitors. The goal is to evaluate these novel heparanase inhibitors in murine models as a...
- This Project Grant award of $830,500.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research investigating the role of glycosphingolipids in kidney disease associated with diabetes and obesity. The key objectives are to: Test whether inhibiting glucosylceramide synthesis in podocytes, renal tubules, or the immune system can prevent progression of kidney disease in mouse...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $478,011 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Trustees of Boston University's Medical Campus. This 2-year grant, with a period of performance from September 2025 to August 2027, will fund the development of a novel deep learning framework to automate the analysis of kidney transmission electron microscopy (TEM) images. The goal is to create an AI-based tool that can accurately measure glomerular basement membrane and podocyte foot process widths, which are critical image-based biomarkers for diagnosing and classifying kidney diseases. This work aims to address the current limitations of manual TEM image analysis, which is labor-intensive and introduces significant inter-operator variability.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $478.0k | 9/11/25 |