Project Grant K25DK143375
- This $728,513 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a renal quantitative susceptibility mapping (QSM) technique for reliable detection and quantification of hemorrhagic cysts as a prognostic biomarker of kidney function decline in autosomal dominant polycystic kidney disease (ADPKD). The key objective is to leverage QSM...
- This $305,844 Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will support an AI-based image phenotyping repository core at Weill Medical College of Cornell University. The project aims to facilitate translational and basic research on polycystic kidney disease (PKD) by providing access to accurate, comprehensive measurements of PKD features visible on clinical imaging (MRI, CT). The core will fully label and store research...
- This $109,076 Project Grant was awarded on July 1, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Weill Medical College of Cornell University to investigate the structural basis and pharmacological inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which plays a key role in the development and...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $640,001 to Yale University to conduct research on the mechanisms and function of the protein Polycystin-1 (PC1) in the context of autosomal dominant polycystic kidney disease (ADPKD). The key objectives are to: 1) determine if a specific 200 amino acid fragment of PC1 can...
- This federal Project Grant award of $342,002.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at Western Michigan University Homer Stryker M.D. School of Medicine (WMED) to develop novel cellular tools for studying the regulation of the PKD1 gene in autosomal dominant polycystic kidney disease (ADPKD). The research aims to...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $478,011 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Trustees of Boston University's Medical Campus. This 2-year grant, with a period of performance from September 2025 to August 2027, will fund the development of a novel deep learning framework to automate the analysis of kidney transmission electron microscopy (TEM) images. The goal is to...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $739,540 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of Columbia University in the City of New York for the development and validation of a third-generation polygenic score (GPS) for chronic kidney disease (CKD). The goal is to improve personalized risk prediction and accelerate the clinical implementation of polygenic prediction in...
- This federal Project Grant award of $155,011 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting research to develop a deep learning model combining magnetic resonance (MAG3) renal scans and kidney ultrasound imaging data to more accurately diagnose unilateral ureteropelvic junction obstruction (UPJO) in children with antenatal hydronephrosis. The research...
- This Project Grant award of $404,883 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop integrated spatial transcriptomics and proteomics technologies for studying kidney disease. The project, titled "Submicron-Resolution Integrated Spatial Transcriptomics and Proteomics for Studying Kidney Disease", will optimize a high-resolution spatial...
- This federal Project Grant award in the amount of $1,695,959.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research to evaluate the use of gadolinium-free kidney functional magnetic resonance imaging (MRI) as a non-invasive method to identify high-risk phenotypes in patients with chronic kidney disease (CKD). The key products and...
This Project Grant award for $124,284 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research conducted by Weill Medical College of Cornell University. The key objectives are to: Develop a super-resolution deep learning framework to generate high-resolution 3D MRI volumes for enhanced monitoring of Autosomal Dominant Polycystic Kidney Disease (ADPKD), incorporating multiple imaging planes to improve biomarker calculation. Create a multi-class, multi-sequence deep learning framework for ADPKD severity assessment, involving segmentation and object detection models to characterize different cyst classes within the kidneys, liver, and pancreas. Build a prognostic model to predict estimated glomerular filtration rate (eGFR) decline and disease progression, with a focus on using cyst class information, particularly hemorrhagic cysts, to improve forecasts. The award period runs from August 1, 2025 to July 31, 2030, supporting this comprehensive research initiative aimed at transforming qualitative ADPKD analysis into quantitative assessment through advanced imaging techniques and predictive modeling.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $124.3k | 8/1/25 |