Project Grant R21DE036367
- The National Institute of Dental and Craniofacial Research awarded Baylor College of Medicine $453,797 on June 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the structures and functions of natural products in periodontal disease. The funded research centers on a novel biosynthetic gene cluster found in clinical isolates of Porphyromonas gingivalis that appears to encode an antibiotic selective for other P. gingivalis strains and related oral...
- The National Institute of Dental and Craniofacial Research awarded the University of Texas Health Science Center at Houston $429,000 on July 16, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate how dietary composition influences Fusobacterium nucleatum physiology and virulence. The project will define the mechanism by which fruit peel extracts induce amyloid fibrils on F. nucleatum surfaces and re-examine the molecular model of amyloid genesis. The...
- The National Institute of Dental and Craniofacial Research awarded Loma Linda University $358,823 on September 11, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct structural-functional studies of gingipain biogenesis and localization in periodontitis research. The research addresses therapeutic gaps in managing periodontitis, a chronic disease linked to systemic diseases including atherosclerosis, rheumatoid arthritis, cancers, diabetes, and Alzheimer's...
- The National Institute of Dental and Craniofacial Research (NIDCR), a component of the Department of Health and Human Services National Institutes of Health, awarded Loma Linda University $631,170 on July 21, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct structural-functional studies of gingipain biogenesis and localization in the context of periodontitis and Porphyromonas gingivalis pathogenesis. The project will expand understanding of...
- The National Institute of Dental and Craniofacial Research awarded Virginia Commonwealth University $101,828 on December 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct functional and structural characterization of phospholipase A2 in Porphyromonas gingivalis, a keystone pathogen of periodontitis. The research delineates the biochemical and structural features of the PG1879 enzyme as a phospholipase A2 and determines its role in the pathophysiology of...
- The National Institute of Dental and Craniofacial Research awarded Virginia Commonwealth University $473,186 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct functional characterization of phospholipase A2 enzymes in Porphyromonas gingivalis, a keystone periodontal pathogen. The research interrogates phospholipase A2 (PLA2) homologs identified in P. gingivalis genomes, specifically examining whether bacterial PLA2 enzymes function as conserved...
- The National Institute of Dental and Craniofacial Research awarded the University of Massachusetts Lowell $100,676 on September 30, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a three-dimensional in vitro human periodontal sulcus tissue model capable of reproducing healthy and disease states of gingivitis and periodontitis. The recipient will engineer a sustained tissue culture system that mimics key anatomical features of the gingival sulcus—including...
- The National Institute of Dental and Craniofacial Research awarded the University of Illinois $320,660 on April 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the immunoregulatory role of dendritic cell subsets in periodontal disease. The award funds research examining how three major dendritic cell subsets—myeloid, lymphoid, and plasmacytoid dendritic cells—respond during periodontal disease resolution and interact functionally with periopathic...
- The National Institutes of Health National Institute of Dental and Craniofacial Research awarded The Trustees Of The University Of Pennsylvania $521,273 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research into dendritic cell and T cell dysregulation in periodontitis associated with poorly controlled diabetes. The project examines how hyperglycemia reprograms dendritic cells and T cells through epigenetic mechanisms, activating...
- The National Institute of Dental and Craniofacial Research awarded The University of Texas MD Anderson Cancer Center $1,470,872 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to elucidate subclonal evolution and fitness dynamics in oral carcinogenesis. The research identifies and interrogates the functional importance of genomic events that drive subclonal selection as oral premalignant lesions (OPL) transform into oral squamous cell carcinoma (OSCC)....
The National Institute of Dental and Craniofacial Research awarded $234,000 to the University of Texas Health Science Center at Houston on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate decoy adhesion mechanisms by which the commensal bacterium Veillonella atypica shields oral epithelial cells from colonization and inflammatory damage by the pathogenic keystone species Porphyromonas gingivalis. The research dissects the molecular and genetic mechanisms of Veillonella atypica's protective function against periodontal disease pathogenesis. Aim 1 will define the domain-specific functions of HAG1, a giant autotransporter adhesin that mediates both Veillonella-epithelial cell adhesion and Veillonella-Porphyromonas coaggregation, using genetic deletion mutants, co-culture assays, and mass spectrometry to identify epithelial receptors and pathogenic adhesin partners. Aim 2 will uncover the genetic repertoire regulating HAG1 expression and broader Veillonella-mediated suppression of Porphyromonas-induced pathogenesis through high-throughput transposon screening, markerless mutagenesis, and RNA-seq to identify key regulatory genes and signaling pathways. The award is structured as a Project Grant to the University of Texas Health Science Center at Houston, with place of performance in Houston, Texas. The period of performance runs from September 1, 2026, through June 30, 2028. This is assistance funding supporting basic and translational research in dental and oral health under NIDCR's extramural research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $234.0k | 9/3/26 |