Project Grant R21DE035645
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $584,420 to the University of Michigan (Regents of the University of Michigan) under the Oral Diseases and Disorders Research program (CFDA 93.121) effective May 1, 2026, through April 30, 2030. This Project Grant supports research to decipher the cellular and genetic mechanisms underlying osteonecrosis of the jaw (ONJ), a serious condition characterized by exposed and necrotic bone...
- Federal Grant Award Summary The University of Florida received a $639,248 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 1, 2025, with completion scheduled for May 31, 2027. This award supports statistical methodology development and secondary analysis of the National Health and Nutrition Examination Survey (NHANES) to assess person-level marginal associations between...
- Federal Grant Award Summary The University of Florida Division of Sponsored Research received a $623,879 Project Grant awarded July 9, 2026, by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). This research grant, with a completion date of April 30, 2031, funds fundamental research on ecological approaches for dental caries prevention and management. The project investigates how prebiotics—specifically...
- Federal Grant Award Summary Award Details: The National Institute of Dental and Craniofacial Research (NIDCR) awarded Augusta University Research Institute, Inc. a Project Grant totaling $645,009 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award period runs from June 15, 2025, through June 14, 2027. Research Scope: This grant funds a research project investigating the molecular mechanisms of alveolar bone loss in periodontitis through examination of...
- Federal Project Grant Award Summary The University of Florida's Division of Sponsored Research received a $574,966 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 5, 2026, with a completion date of February 28, 2030. This research initiative, conducted in Gainesville, Florida, investigates functional amyloid formation in Streptococcus mutans, the primary pathogen responsible...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Florida a $307,000 Project Grant effective July 15, 2025, through July 14, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121). This research initiative investigates the expression of cellular senescence markers in gingival tissue biopsies to elucidate the mechanisms by which Type 2 diabetes mellitus (T2DM) contributes to periodontal disease...
- Federal Grant Award Summary The University of Texas Medical Branch at Galveston received a $323,000 Project Grant award dated July 9, 2026, from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant supports a two-year research initiative (through July 8, 2028) focused on modeling causal mediation by dental care and developing risk prediction tools for osteonecrosis of the jaw (ONJ) in bisphosphonate...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded the University of Florida Division of Sponsored Research a $411,775 Project Grant effective July 7, 2026, through July 6, 2028. This research initiative investigates the molecular mechanisms by which Streptococcus gordonii, a pioneer colonizer of the oral cavity, senses and adapts to fluid shear forces generated by...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Maryland, Baltimore a Project Grant totaling $427,625 under the Oral Diseases and Disorders Research program (CFDA 93.121) for the period July 1, 2025 through June 30, 2027. This research project will investigate the causal relationship between denosumab (DMAB) therapy and multiple external cervical root resorption (MECRR), a pathological condition affecting permanent teeth....
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Florida's Division of Sponsored Research a Project Grant of $325,176 on August 8, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop artificial intelligence (AI)–derived multilevel social risk scores for oral cavity and oropharyngeal cancer (OCC/OPC) patients. The research addresses critical gaps in timely diagnosis and treatment access for...
The University of Florida, Division of Sponsored Research, received a $428,188 Project Grant award dated July 9, 2026, from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The two-year project, concluding July 8, 2028, will deliver research and development services focused on preventing and treating medication-related osteonecrosis of the jaw (MRONJ), a serious condition affecting cancer patients receiving bone-modifying drugs such as bisphosphonates. The research team will develop and validate an in situ delivery system utilizing an IDO-GAL3 fusion protein—combining indoleamine 2,3-dioxygenase (IDO), an anti-inflammatory enzyme, and galectin-3 (GAL-3), a sugar-binding protein that enhances IDO localization—to suppress inflammation and prevent MRONJ development. The research deliverables will include preclinical efficacy studies using a rice rat model that mimics human MRONJ, evaluation of single and repeated IDO-GAL3 dosing regimens, and comprehensive spatial metabolome and glycome profiling to characterize disease progression and therapeutic response. These research outputs will generate evidence supporting the use of metabolic reprogramming as a novel therapeutic strategy for MRONJ prevention and healing in patients with periodontitis undergoing bisphosphonate treatment, with potential applications extending to related inflammatory conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $428.2k | 7/14/26 |