Project Grant R21DE035273
Award Date 8/8/25
Completion Date 8/7/27
Dollars Obligated $451K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $390,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical College of Wisconsin, Inc. The grant funds a 5-year research project to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The project aims to develop innovative methods to isolate and characterize tumor-infiltrating...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $308,223 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Leland Stanford Junior University (Stanford University). The grant, awarded on July 15, 2025, supports research to define how the gene ACTL6A contributes to metabolic reprogramming in head and neck squamous cell carcinoma (HNSCC). The research aims to quantify energy production in HNSCC cells with varying ACTL6A levels,...
- This $245,504 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to develop new treatment approaches for oral squamous cell carcinoma (OSCC). The project explores targeting the stress-specific functions of the essential DNA replication factor Replication Protein A (RPA) to selectively enhance OSCC treatment responses. Researchers from the University of North Carolina at...
- This Project Grant award of $315,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The goal of this 2-year project is to study the role of the TRPC1 protein as a potential therapeutic target for treating oral squamous cell carcinoma (OSCC), a common and deadly type of head and neck cancer. The research will focus on understanding how TRPC1 mediates calcium...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $219,660 Project Grant to the Regents of the University of Michigan to conduct research on "Intercepting the Evolution of Pro-Tumoral Myeloid Cells During the Initiation of Oral Cancer". This project aims to investigate how myeloid cells in precancerous lesions develop suppressive phenotypes that inhibit anti-tumor immune...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $716,123 Project Grant to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Florida. The grant, awarded on September 8, 2025, aims to establish a clinical cohort and develop novel analytical methodologies to validate, discover, and optimize non-invasive liquid biopsy tests for prognosis prediction in head and...
- This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $616,000 Project Grant to the Rowan University School of Osteopathic Medicine. This grant, with a performance period from Aug 1, 2025 to Jul 31, 2029, will support research investigating the use of the Hedgehog signaling pathway inhibitor drug sonidegib as a potential therapeutic strategy for oral squamous cell carcinoma (OSCC). The key...
- This federal Project Grant award of $483,360.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to target vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry for developing new precision therapies for oral cancer. The project aims to explore synthetic lethal and gene interaction networks to expose druggable systems vulnerabilities and uncover mechanisms of...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $129,289 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Leland Stanford Junior University. The grant funds research to develop lysosome-targeting chimeras (LYTACs) that can degrade immune checkpoint proteins and enhance immunoradiotherapy for head and neck cancer. The project aims to evaluate the impact of LYTACs on immune cell modulation and their therapeutic potential in...