This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $442,750 over 2 years to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The funding will support a research project to systematically identify the drivers controlling the interactions between the bacterium Fusobacterium nucleatum and oral squamous cell carcinoma. Specifically, the project aims to 1) identify tumor cell determinants of Fusobacterium invasion and altered tumor cell viability, and 2) identify microbial determinants of Fusobacterium intracellular colonization of tumor cells. By integrating functional genomics on both the tumor and bacterial cells, the project seeks to provide a mechanistic understanding of the Fusobacterium-tumor cell interactions, with the goal of enabling therapeutic manipulation of these interactions.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $442.8k | 6/25/25 |