Project Grant R21DE034942
Award Date
7/15/25
Completion Date
7/14/27
Dollars Obligated
$451K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Similar Awards
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $642,488 to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The funding will support a 5-year research project focused on understanding the mechanisms by which human papillomavirus (HPV) promotes immune evasion in head and neck squamous cell carcinomas (HNSCC)....
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $315,000 to The Ohio State University to develop novel antibody therapeutics targeting the human papillomavirus (HPV) oncoproteins E6 and E7. The goal is to leverage the university's unique platform of HPV-specific human monoclonal antibodies to generate dimeric IgA molecules that can efficiently inhibit the growth of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $204,688 to The Johns Hopkins University from May 1, 2025 to April 30, 2027. The project aims to evaluate and compare the ability of Salmonella-derived nanoparticles (SAL-9RE7 and SOMV-9RE7) to mediate tumor control and induce HPV E7-specific T cell immunity. It will also evaluate the potency of a combination treatment...
This Project Grant award of $229,440 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the mechanisms driving differential responses to a novel radio-immunotherapy combination in preclinical models of head and neck squamous cell carcinoma (HNSCC) and pancreatic adenocarcinoma (PDAC). The research aims to elucidate how regulatory T cells mediate the divergent responses...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $515,812 to The Johns Hopkins University to study the progression of HPV-related oropharynx cancer (HPV-OPC) and how it differs between individuals with and without HIV. The study aims to: 1) characterize the impact of HIV on oral HPV16 persistence, 2) evaluate the performance of oral and blood biomarkers for...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $483,360 to the University of California, San Diego (UCSD) to conduct research aimed at identifying new precision therapies for oral cancer. The key focus is to exploit vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry to disrupt immune evasive mechanisms and enhance the activity of anti-PD-1...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Arizona in the amount of $118,763 for the period of September 1, 2024 to August 31, 2026. The grant will support Dr. Robert Jackson's research focused on assessing the role of human papillomavirus type 16 (HPV16) in transforming versus productive infections in oral epithelial tissues. The research aims to characterize the viral...
This federal Project Grant award of $2,740,126, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the mechanisms by which HIV infection contributes to the development of oropharyngeal cancer (OPC) in people living with HIV (PWH). The key objectives are to: 1) Determine the HPV types present in OPC from PWH and how T cell-mediated anti-tumor immunity is impaired;...
This Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides $699,929 to the University of California, San Diego (UCSD) to conduct research aimed at enhancing dendritic cell migration to draining sentinel nodes in order to improve immunotherapy response in human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC). The research project seeks to define the functional state of dendritic cells in tumor and draining sentinel...
This Project Grant award of $156,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to determine the sex-specific differences in the immune microenvironment of head and neck squamous cell carcinoma (HNSCC). The research aims to 1) characterize sex-specific myeloid cell differences and activities in HNSCC tumor models, 2) investigate the impact of depleting neutrophils on...