This federal Project Grant award for $999,776.00, awarded on Sep 13, 2024 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to advance oral health equity through strengthening the scientific basis for innovations in population-based approaches to improving dental care access, utilization, and quality. The research program will incorporate a framework that integrates multi-level perspectives and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $161,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Case Western Reserve University. The grant, which runs from August 1, 2024 to July 31, 2026, will support the development of new statistical methods for analyzing the causal effects of individual components within bundled interventions. This research aims to address the challenge of evaluating the impact of specific...
This federal Project Grant award, totaling $236,250.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The award supports a study investigating the potential biological mechanisms underlying the association between adverse childhood experiences (ACEs) and increased risk of dental caries in children. The study aims to examine the relationships among ACEs, the oral microbiome,...
This $3,471,873 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a multidisciplinary research effort to develop a new class of anticaries treatments. The project aims to leverage species-specific susceptibilities to fluoride in order to revert cariogenic biofilm dysbiosis and eliminate early childhood caries (ECC), a major global health problem affecting over 500 million...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $163,411 to The Ohio State University for research on the interactions between oral bacteria that contribute to dental caries (cavities). The project aims to understand how disease-associated bacteria, such as Streptococcus mutans, compete with commensal oral bacteria for carbohydrate sources and form...
This $294,632 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to develop an intraoral camera system that can detect and monitor early-stage dental caries (tooth decay) using targeted fluorescent nanoparticle technology. The awarded project, led by Greenmark Biomedical Inc., will prepare a minimally viable product (MVP) of the intraoral camera system and conduct...
This federal Project Grant award of $593,468 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to elucidate the role of the TRPS1 transcription factor in regulating dental tissue formation and susceptibility to dental caries. The research aims to: (1) determine how TRPS1 affects communication between developing odontoblasts and ameloblasts and the formation of mantle dentin; and (2)...
This federal Project Grant award of $745,966.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to Oregon Health & Science University (OHSU) on May 18, 2024. The purpose of this grant is to investigate a novel biosynthetic gene cluster (BL-BGC) in the bacterium Streptococcus mutans, which is commonly associated with severe early childhood caries (SECC). The research aims to characterize...
This $162,216 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports the ADA Forsyth Institute's research to investigate microbe-microbe interactions within the oral microbiome. The study aims to employ a combination of expansion microscopy and multiplex FISH imaging to analyze microbial organization and quantify adhesion forces at the single-cell level. This approach...
This $156,589 federal Project Grant award was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research grant program (CFDA 93.121). The purpose of this 5-year grant is to leverage electronic health record (EHR) data to develop advanced machine learning models that can predict emergency department use for non-traumatic dental conditions, particularly among vulnerable populations. The award aims to: 1) use EHR and social...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $219,132 to Virginia Commonwealth University (VCU) to develop a pragmatic, nationally-representative index for assessing dental caries experience.
The project aims to: 1) construct and validate a single interpretable index model using DMFS/T counts; 2) refine and validate the index for spatially-referenced tooth-surface level binary outcomes; and 3) produce free software for estimating the personalized caries experience index. This research will generate new knowledge on national-level caries evaluation by moving beyond traditional DMFT/S indices and providing advanced statistical methods for analyzing complex, large-scale dental survey data. The award period is from May 1, 2025 to April 30, 2027.