Project Grant R21DC021785
- This $496,496 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports the development of chemical probes to improve diagnosis and treatment of otitis media (OM), or middle ear infection. The primary aim is to create fluorescent probes that can covalently label bacterial enzymes involved in cell wall formation, enabling specific...
- This Project Grant award of $306,872, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports the development of a safe, low-power digital laser otoscope by Mstatt LLC (doing business as North Coast Photonics) to improve the identification and diagnosis of otitis media with effusion (OME) in young children. OME is a common cause of childhood hearing loss, with an...
- The National Institute on Deafness and Other Communication Disorders (NIDCD), through its Research Related to Deafness and Communication Disorders program (CFDA 93.173), awarded a $306,311 project grant to AO Technologies, LLC on July 10, 2025 to develop a high-performance, reduced-cost optical coherence tomography (OCT) otoscope. This device aims to provide improved three-dimensional imaging and diagnostic capabilities for examining the tympanic membrane and middle ear, which has seen little...
- This $533,978 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research to uncover the molecular basis of otosclerosis. The project aims to analyze rare and common genomic variants in a large cohort of otosclerosis cases and families, as well as identify epigenetic factors implicated in the disease, using advanced genomic and...
- This $473,749 Project Grant was awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) on September 11, 2025. The grant is for a project titled "In-silico Screen and In-vivo Evaluation of FDA-Approved Drugs to Treat Noise-Induced Hearing Loss" conducted by the Massachusetts Eye And Ear Infirmary, a non-profit hospital and research institution affiliated with Harvard...
- The federal Project Grant award of $415,743.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research by Oregon Health & Science University (OHSU) on the origins and roles of macrophages in the development, homeostasis, and repair of the tympanic membrane (eardrum). The 5-year project, commencing on February 1, 2025, aims to investigate the fundamental...
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), is funding the development of a novel, low-cost imaging device based on optical coherence tomography (OCT). The device enables real-time, 3D visualization of the tympanic membrane and middle ear, allowing for early detection of various ear disorders that often go undiagnosed until...
- This Project Grant award, valued at $674,021 and funded by the National Institute on Deafness and Other Communication Disorders (NIDCD), supports the "Advancement of an Implantable Microphone" under the NIDCD's "Research Related to Deafness and Communication Disorders" grant program (CFDA 93.173). The award is focused on refining and validating an innovative implantable microphone prototype, called the UMIC, that was previously developed through NIDCD funding. The UMIC is...
- This federal Project Grant award of $305,628 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) supports the development of a cell-type-specific gene therapy approach for TOMT-linked congenital hearing loss. The awardee, Echogenesis Therapeutics Inc., is using a computational platform to generate candidate cell-type-specific genomic promoter fragments for precise therapeutic...
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders federal grant program (CFDA 93.173), will support research to visualize the fluid compartments of the human inner ear using optical coherence tomography (OCT) imaging. The $1,403,696 award aims to characterize the normal endolymph-to-perilymph ratio in control subjects and compare it to subjects with Meniere's disease and...
This $489,500 Project Grant was awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), to The General Hospital Corporation (doing business as Massachusetts General Hospital) to explore the use of antimicrobial blue light for the treatment of otitis media (OM), the most common pediatric infection. The key objectives of this 2-year project are to: 1) investigate the in vitro efficacy of antimicrobial blue light in killing primary otopathogens, including planktonic bacteria and mono/polymicrobial biofilms; and 2) evaluate the safety of antimicrobial blue light exposure on human middle ear cells. This research aims to assess the potential of antimicrobial blue light as an effective and safe non-pharmaceutical treatment option for otitis media, reducing the reliance on systemic antibiotics and addressing the rise of antibiotic resistance.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $489.5k | 8/1/25 |