This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development of chemical probes to enable imaging and phototherapeutic treatment of otitis media (OM), a common middle ear infection primarily affecting children. The $496,496 award to The Leland Stanford Junior University will fund research focused on three primary aims: 1) developing a covalent probe targeting bacterial D,D-carboxypeptidases to specifically detect OM-causing bacteria, 2) demonstrating the probe's ability to both image and kill the five most common OM-causing bacteria in vitro, and 3) validating the probe's effectiveness for imaging and clearing these bacteria in a mouse model of OM. This innovative approach seeks to provide a new diagnostic and treatment strategy for OM that can reduce antibiotic overuse and the growing threat of antimicrobial resistance.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $496.5k | 7/23/25 |