Project Grant R21DA066890
- Federal Project Grant Award Summary Yale University received a $659,834 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective June 15, 2026, through March 31, 2031. The funded research investigates cannabinoid receptor type 1 (CB1R) availability in individuals with opioid use disorder (OUD) to address a critical gap in understanding the endocannabinoid system's role in relapse risk and emotional...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $451,670 Project Grant to Massachusetts General Hospital on May 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports the final preclinical evaluation and development of 18F-fluorocarfentanil (18F-FCFN), a next-generation positron emission tomography (PET) neuroimaging probe designed to safely and accessibly measure mu opioid receptor (MOR) density and occupancy in the human...
- Federal Grant Award Summary Yale University received a $1.15M Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded July 15, 2025, with completion targeted for March 31, 2030. The Y-SCORCH 2.0 project conducts advanced data mining and functional characterization of single-cell opioid responses in the context of HIV infection. The research leverages 346 existing single-nucleus transcriptomic and epigenetic datasets...
- Federal Grant Award Summary Yale University received a $197,024 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 30, 2025, with a completion date of June 30, 2027. The grant funds two multi-methods research studies examining the impact of xylazine, a veterinary tranquilizer emerging as an adulterant in the unregulated opioid supply, on people who use drugs (PWUD). The first study, conducted in North...
- Federal Grant Award Summary Yale University received a $641,138 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective June 15, 2026, through March 31, 2030. The award funds a comprehensive epidemiological study investigating methadone dose-associated risks and outcomes in opioid use disorder (OUD) treatment, with particular emphasis on aging populations. The research leverages a national cohort of...
- Federal Grant Award Summary Yale University received a $2.26 million Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded March 1, 2026, with a completion date of February 28, 2030. The award supports research investigating genetic effects on molecular phenotypes at single-cell resolution across brain regions in individuals with substance use disorder (SUD) and HIV infection. The project applies state-of-the-art...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Yale University a $336,250 Project Grant (CFDA 93.279: Drug Use and Addiction Research Programs) effective April 1, 2026, through March 31, 2028, to develop a novel behavioral foundation model that leverages large-scale epidemiological survey data to advance substance use disorder (SUD) research. The award supports the creation of a machine learning system that harmonizes data from the National...
- Federal Grant Award Summary Yale University received a $357,613 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) effective June 1, 2025, through May 31, 2027. The award funds a research initiative titled "Finding the Missing Parts of Human Genetics of Substance Use Disorders," which leverages large-scale whole-genome sequencing (WGS) data from publicly available biobanks, including the All of Us...
- Federal Project Grant Award Summary Yale University received a $195,048 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 1, 2025 through August 31, 2030. This award supports the development of a culturally adapted Contingency Management (CM) intervention for adults with Stimulant Use Disorder in New Haven, Connecticut. CM is a behavioral economics-based intervention that uses tangible positive...
- Federal Grant Award Summary Yale University received a $190,580 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective March 1, 2026 through February 28, 2031. This K23 career development award supports the development and pilot testing of a multiple health behavior change (MHBC) intervention targeting concurrent weight loss and smoking cessation among pre-bariatric surgery patients. The project will...
Yale University received a $462,625 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), with performance extending from July 1, 2026, through June 30, 2028. This award supports preclinical evaluation of fluorine-18 labeled positron emission tomography (PET) radiotracers designed to image mu opioid receptors (MOR). The research addresses a critical gap in diagnostic imaging capabilities, as the only currently validated MOR imaging agent—[11C]carfentanil—has been in use for four decades but suffers from severe practical limitations due to its short radioisotope half-life, resulting in minimal clinical adoption worldwide. The deliverables under this grant include advanced characterization and validation of three new 18F-labeled MOR tracers in non-human primate PET studies. Building upon encouraging preliminary data from rodent and non-human primate imaging experiments that demonstrated strong correspondence with existing standards and specific, displaceable binding properties, Yale's research team will further evaluate these tracers to advance them toward potential human clinical applications. The development of improved 18F-labeled alternatives would substantially expand access to MOR imaging by overcoming logistical constraints associated with shorter-lived radioisotopes, enabling broader clinical utilization for addiction research, pain management assessment, and opioid receptor dysfunction studies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $462.6k | 6/19/26 |