Project Grant R21DA065088
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Feinstein Institutes For Medical Research a $616,372 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning July 15, 2025, with a completion date of March 31, 2030. This award supports research investigating transposable element (TE) expression and regulation in the context of HIV-1 infection and cannabinoid exposure at the single-cell and nuclei level. The research leverages a...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of California, San Diego a $3.73 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning April 15, 2025, with a completion date of January 31, 2030. This research initiative investigates the mechanistic intersection of human immunodeficiency virus (HIV) and opioid use on inflammasome-mediated neuroinflammation and neurotoxicity in the central nervous system...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University a Project Grant (R21) totaling $439,180 under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period September 1, 2025 through August 31, 2027. This high-risk/reward research initiative investigates dopaminergic neuronal-glial interactions in the striatum to advance understanding of cognitive dysfunction and chronic pain experienced by people living with HIV (PLWH)...
- Federal Grant Award Summary The National Institute on Drug Abuse awarded The Children's Hospital of Philadelphia Research Institute a $534,000 Project Grant effective September 1, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the lifespan effects of prenatal and perinatal opioid exposure on the brain's metabolic-epigenetic axis. The research addresses a critical gap in neuroprotective treatment development by examining how opioid exposure during fetal...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $685,937 Project Grant to the University of Maryland, Baltimore, effective March 15, 2026, through December 31, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research initiative investigates the impact of opioid use disorder (OUD) on mitochondrial dysfunction in antiretroviral therapy (ART)-receiving aging people with HIV (PWH). The research addresses a critical gap in understanding...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Children's Hospital of Philadelphia Research Institute a Project Grant totaling $389,816 under the Drug Use and Addiction Research Programs (CFDA 93.279) on June 16, 2025, with completion targeted for January 31, 2027. This two-year research initiative investigates the neural mechanisms underlying fentanyl-linked context memories to develop novel therapeutic approaches for preventing addiction relapse. The...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University a $465,250 Project Grant effective September 1, 2025 through August 31, 2027 under the Drug Use and Addiction Research Programs (CFDA 93.279). This award supports a human laboratory research study investigating pregnenolone as a potential pharmacological treatment for cannabis intoxication. The research will conduct a within-subjects, double-blind, placebo-controlled clinical trial with...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $245,562 under the Drug Use and Addiction Research Programs (CFDA 93.279) effective June 23, 2025, with completion targeted for December 31, 2027. This research project investigates the combined effects of nicotine and NLRP3 inflammasome activation on human immunodeficiency virus (HIV)-1-associated central nervous system (CNS) inflammation. The...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Medical University of South Carolina a Project Grant totaling $686,692 under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, with completion anticipated by July 31, 2030. This award supports a prospective clinical research trial designed to assess the benefits of cannabis use reduction in adults with Cannabis Use Disorder (CUD). The research addresses a significant evidence...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $621,186 Project Grant to the University of Wisconsin-Milwaukee under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period of July 1, 2025 through March 31, 2030. This research project will examine the longitudinal impact of circulating endocannabinoid (ECB) levels on neurocognition, impulsivity, and early cannabis use patterns in youth enrolled in the Adolescent Brain Cognitive Development...
The National Institute on Drug Abuse (NIDA) awarded The Children's Hospital of Philadelphia Research Institute a $456,268 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning March 1, 2026 and concluding February 29, 2028. The project, titled "Antioxidant and Blood Flow Profiling in Individuals with HIV," investigates the neurobiological effects of marijuana consumption methods among people living with HIV (PWH). The research will utilize advanced edited magnetic resonance spectroscopy (MRS) to assess glutathione (GSH) levels—a marker of oxidative stress in the brain—and measure cerebral blood flow (CBF) across five participant groups: PWH marijuana smokers, PWH marijuana edible users, PWH tobacco smokers, PWH non-users of either substance, and seronegative controls. Comparative analysis will evaluate how marijuana smoke toxins affect antioxidant protection and cognitive function in PWH relative to tobacco smoke and edible consumption. The project delivers two primary research aims designed to address a knowledge gap regarding marijuana edibles' impact on cognitive function in PWH and to elucidate mechanisms by which smoking-based consumption contributes to oxidative stress and neuronal vulnerability. This research supports NIDA's mission to develop new knowledge and approaches for understanding substance use's health outcomes, including HIV/AIDS-related comorbidities, through translational investigation of drug consumption methods and their physiological consequences in vulnerable populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 3/11/26 | ||
| Not listed | $456.3k | 2/20/26 |