Project Grant R21DA064062
- The federal Project Grant award of $1,465,275.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the role of HIV proteins in psychostimulant abuse, specifically focused on understanding how HIV and HIV viral proteins alter the molecular actions and behavioral expressions of amphetamine. The project aims to elucidate the mechanisms by which HIV infection and HIV proteins, such as Tat and gp120,...
- The National Institute on Drug Abuse (NIDA), under CFDA Program 93.279 - Drug Use and Addiction Research Programs, awarded a $1 project grant to the J. David Gladstone Institutes. The grant aims to establish a novel mouse model for studying the impact of HIV and addictive substances on the central nervous system. Specifically, the project will develop a chimeric mouse model with human microglia, neurons, and astrocytes derived from induced pluripotent stem cells. This model will be used to...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $608,652 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Scripps Research Institute. The purpose of this 5-year award, with a start date of September 1, 2025, is to conduct data mining and functional validation of the Systematic Characterization of Retroviral Conditions for Health (SCORCH) datasets. The research aims to elucidate the key pathogenic...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $558,668 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Massachusetts Institute of Technology (MIT) for the project "Integration and Validation of Single-Cell Neuronal and Immune Molecular Responses in SUD and HIV". The project aims to uncover the genetic and molecular mechanisms driving the interactions between HIV, neuropsychiatric, and...
- This federal Project Grant award of $240,108 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to elucidate the corticostriatal and neuroimmune mechanisms underlying HIV-induced dysregulation of reward seeking. The award to Drexel University will support research to identify novel treatment targets for individuals with co-occurring cocaine use disorders and HIV. The project will leverage animal models to investigate how HIV...
- This federal Project Grant award, valued at $563,742.00, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research to investigate the impact of HIV infection and cocaine use on lipid metabolism in microglia, a type of brain cell, and the role this plays in the development of neurological symptoms associated with HIV (referred to as NeuroHIV). Key research activities include: Examining how HIV proteins...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a comprehensive effort to analyze hundreds of multi-omic datasets related to the impact of substance use disorders (SUD) and HIV on the brain's reward circuitry and neuroinflammation. The $556,432 award, commencing on September 1, 2025, will enable researchers at the University of Maryland, Baltimore to: Assemble a harmonized resource of...
- This Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the effects of opioids on HIV transcription and latency. The $234,000 award to Georgetown University will support research using a novel dual fluorescent and bioluminescent virus called EcoHIV NL4-3 Dual Red to visualize active HIV proviral transcription in microglia and astrocytes. The study will examine the mechanisms by which...
- This federal Project Grant, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $804,728 to the Regents of the University of California at Riverside to investigate the role of the cysteinyl leukotriene-cysteinyl leukotriene receptor 1 (CYSLT-CYSLTR1) axis in promoting HIV-1 persistence and brain injury in individuals living with HIV who use methamphetamine. The 5-year project, starting June 1, 2025, aims to determine...
- This $4.9 million project grant from the National Institutes of Health's National Institute on Drug Abuse will support research at The Johns Hopkins University from April 2022 to March 2026. The grant is part of the Drug Abuse and Addiction Research Programs (CFDA 93.279), which aims to develop new knowledge around prevention, diagnosis, treatment and causes of drug abuse and addiction. Specifically, the university will leverage rare longitudinal social and spatial network data along with...
The federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $439,180 to The Johns Hopkins University to investigate the role of dopaminergic neuron-glial interactions in the striatum in the context of HIV infection and substance use disorders. The research aims to deconvolute the complex interplay between HIV, methamphetamine use, and alterations in dopamine signaling pathways, which can contribute to cognitive dysfunction and chronic pain in people living with HIV. The project will leverage expertise in HIV-TAT transgenic animal models to elucidate the mechanisms by which the mammalian target of rapamycin (mTOR) pathway and secreted phosphoprotein-1 (OPN/SPP1) signaling modulate microglial-dopaminergic neuron crosstalk in this disease setting. The award period runs from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $439.2k | 8/22/25 |