The National Institute on Drug Abuse (NIDA) awarded a $687,416 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, CA. The grant supports research to develop therapeutically effective latency-promoting agents (LPAs) that can "block" HIV reactivation and "lock" HIV in a silenced state, even in the presence of addictive substances, for people living...
This federal Project Grant award of $1,454,724 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to understand the mechanisms involved in HIV-1 latency in the central nervous system (CNS). The award aims to identify key factors, pathways, and regulators that determine the establishment, maintenance, and reactivation of latent HIV-1 virus in brain myeloid cell lineages, which are considered viral reservoirs in the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,223,769 to the University of California, San Diego (UCSD) to conduct research on the intertwined mechanisms of HIV and opioid use on mitochondrial-mediated inflammasome activation and neurotoxicity. The research aims to elucidate how the convergence of HIV infection and opioid use leads to more severe neurological consequences, including...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $489,500 to The Children's Hospital of Philadelphia Research Institute to investigate the cellular identity of the intact HIV reservoir. The key objectives are to: 1) Test the hypothesis that CD4+ T cells with provirus in closed chromatin are transcriptionally distinct from cells with provirus in open chromatin, and 2)...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $486,057 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The 5-year grant, awarded on June 6, 2025, will support the development of a multipronged mRNA gene therapy approach to address HIV persistence and enable a potential cure. The proposed research aims...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $1,475,580 to The Regents of the University of California, San Francisco (UCSF) to conduct in-depth spatial characterization of HIV-host cellular interactions within the central nervous system (CNS) of people living with HIV (PWH) who died suddenly. The key objectives are to: (1) implement innovative spatial multi-omic assays to analyze the...
The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,470.00 in funding to Drexel University to develop a new imaging pipeline and analytical approach for examining the spatial architecture of histone dopaminylation in the central nervous system (CNS) of mice with HIV infection that self-administer cocaine. The goal is to connect molecular-level epigenetic changes with behavioral outcomes...
This Project Grant award of $2,312,085, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the molecular mechanisms linking HIV infection and opioid use disorder that contribute to neuroinflammation and HIV-associated neurocognitive disorders (HAND). The research, led by the Trustees of Boston University's Medical Campus, will utilize primary human iPSC-derived microglia cultures to...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $240,108 to Drexel University to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the dysregulation of reward-seeking behavior in the comorbid condition of HIV and cocaine use disorder (CUD). The research aims to use circuit-specific optogenetics and chemogenetics in mouse models to understand how HIV infection,...