This Project Grant award, totaling $181,040.00, was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award aims to create an immersive training experience for the applicant to develop a unique skillset at the intersection of psychiatric genetics, substance use disorder (SUD) epidemiology and health disparities, SUD psychopharmacology, clinical informatics, and bioinformatics. The research will leverage the Million Veteran...
This $715,238 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) is focused on conducting a large-scale genome-wide association study (GWAS) to elucidate the genetic basis of opioid-related traits and opioid use disorder (OUD). The key objectives are to: 1) Deploy a survey to 500,000 diverse participants from 23andMe to collect data on pre-addiction phenotypes (e.g., initial opioid use, subjective opioid response)...
The National Institute on Drug Abuse (NIDA) awarded a $694,219 Cooperative Agreement (CFDA 93.279 - Drug Use and Addiction Research Programs) to the University of California, Los Angeles (UCLA) to identify genes involved in behaviors related to substance use disorder. The project aims to use a novel mechanism-to-gene strategy, integrating genetic and circuit variation, to map the genetic underpinnings of anxiety-related behaviors linked to substance use disorders. Key objectives include...
This $175,888 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to develop novel methods for studying the genetic and neurological mechanisms underlying nicotine and cannabis addiction. The key products and services to be delivered under this 4-year grant include: Developing a new Transcriptome-Wide Association Study (TWAS) method to identify genes associated with changes in brain functional connectivity...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $346,911 to Virginia Commonwealth University (VCU) to conduct a cross-species study on the neurocognitive, genetic, and socio-environmental influences on developmental precursors to substance use disorders. The key objectives of the project are to: 1) Determine how early life environment impacts neurocognitive development and the...
This $397,829 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Federal Drug Use and Addiction Research Programs (CFDA 93.279), supports the development of an AI platform to accelerate the discovery of therapeutics for substance use disorders (SUDs). The key objectives of this 1-year project are to: 1) create curated datasets and machine learning models to expedite drug discovery tasks, 2) identify mechanistic targets for GLP-1 receptor agonist pathways that can...
This federal Project Grant award of $594,784 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support a study to identify novel transcriptomic and epigenetic changes in biological pathways that may serve as biomarkers and therapeutic targets for alcohol use disorder (AUD). The research team at Yale University will perform a postmortem, multi-omic analysis of brain tissue samples from 341 subjects, including those with AUD,...
This $134,311 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund a 5-year "Preparing the Next Generation of Addiction Researchers in Computational AI/ML Techniques" research education program. The program aims to train 8-10 predoctoral and postdoctoral trainees per year in statistical machine learning (SML) and artificial intelligence (AI) techniques applicable to addiction research. Key...
This $399,483 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to generate synergy between artificial intelligence (AI) and DNA-encoded library (DEL) technologies to identify novel multivalent compounds for treating substance use disorders (SUDs). The key objectives are to: 1) use DEL screening to identify compounds that target the opioid receptor delta (OPRD1) and dopamine receptor D3 (DRD3) to...
The National Institute on Drug Abuse (NIDA) awarded a $272,395 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Regents of the University of California, San Francisco (UCSF) to research the role of the epigenetic regulators G9A and GLP in the development of addictive behaviors. The key objectives are to: 1) Identify specific molecular surfaces that enable manipulation of the different G9A/GLP dimers and their chromatin binding activities, and 2) Examine how...