This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $238,500.00 over a 2-year period starting January 1, 2025 to examine the effects of the veterinary sedative xylazine on inhibitory brain circuits in the prefrontal cortex, and how these effects interact with opioid signaling. Specifically, the research aims to 1) test whether xylazine and opioids have synergistic effects on reducing inhibitory...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to investigate the effects of the fentanyl-xylazine drug mixture on cardiorespiratory function and subjective effects in rats. The $423,708 award, effective from September 30, 2024 to September 29, 2026, will allow researchers at the RU School of Osteopathic Medicine to use telemetry, plethysmography, and drug discrimination procedures...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on studying the pharmacological properties of the drug xylazine and its metabolites. The $231,000 award runs from May 1, 2025 to April 30, 2027 and will be conducted by the University of Rochester. The key objectives are to determine if xylazine and its metabolites act as agonists, antagonists, or positive allosteric modulators at the mu,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to better understand the behavioral pharmacology of opioid and xylazine (a veterinary sedative) combinations. The $392,940 award to the University of Texas Health Science Center at San Antonio will conduct experiments using established animal models to investigate why use of opioid/xylazine mixtures has increased, including whether...
This federal Project Grant award, ID R21DA061097, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $387,750 award will support a 2-year research project at Mercer University to investigate the molecular pharmacology of the drug xylazine and its relation to necrotic skin lesions associated with chronic intravenous administration. The key objectives of the project are to: 1) assess the binding affinity of xylazine...
The National Institute on Drug Abuse (NIDA) awarded a Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) totaling $907,500 to Trustees of Tufts College, doing business as Tufts University School of Medicine. The grant, titled "Examination of Xylazine Exposure and the Risk of Skin and Soft Tissue Infections in People Who Inject Drugs," will run from September 15, 2024 to August 31, 2026. The project aims to prospectively recruit 200 people who inject drugs (PWID)...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $408,486 to the Research Triangle Institute (RTI International) to conduct a community-based, longitudinal, mixed-methods study investigating the growing crisis of xylazine exposure among people who use drugs in the Southeastern U.S. The study aims to: 1) employ community-based drug checking to determine the prevalence of xylazine in the illicit drug...
The National Institute on Drug Abuse (NIDA) awarded a $223,715 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Washington to explore the neurobehavioral effects of concurrent opioid and methamphetamine use disorders. The key objectives are to: 1) Define the behavioral profile of dual opioid-methamphetamine use disorders in a rodent model, comparing polysubstance and mono-substance addiction patterns, and 2) Map neural activation patterns within...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Federal Grant Program "Drug Use and Addiction Research Programs" (CFDA 93.279), provides $266,742 in funding to Yale University to conduct a two-year qualitative study. The study aims to characterize transitions to low-frequency injecting and injection cessation among people using xylazine-adulterated fentanyl in Connecticut, one of the states most impacted by this drug supply change. The research will...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,185,966 over a 5-year period to investigate the relationship between short sleep duration and vulnerability to methamphetamine intake. The study, conducted at the University of Mississippi Medical Center, aims to evaluate how dysregulation of the orexin (hypocretin) neurotransmitter system contributes to short sleep patterns in female...