Project Grant R21DA062207
- This Project Grant award of $149,804 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to identify new genetic regulators that influence opioid signaling pathways. The goal is to expand understanding of the opioid signaling landscape and identify potential genetic targets to tune signaling biases for safer and more effective opioid treatments. The University of Florida is the awardee and will implement a MOR-MAPK...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), part of the U.S. Department of Health and Human Services, is funded through the Drug Use and Addiction Research Programs (CFDA 93.279). The $454,251 award will support the development of a new approach for long-term monitoring of opioid-induced changes in neural population activity and opioid receptor gene expression in mice exposed to fentanyl. Specifically, the project aims to create "erasable"...
- This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the CFDA program "Drug Use and Addiction Research Programs" (93.279), will support research to uncover the neurophysiological signatures within the addiction circuitry related to acute opioid use. The $159,711 award, effective January 1, 2025 through December 31, 2029, will leverage a unique ability to directly record local field potentials from awake humans with implanted brain electrodes. This will...
- This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
- This $129,132 project grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to characterize distinct subpopulations of dopamine neurons in the ventral tegmental area (VTA) and examine their unique responses to cocaine and fentanyl. Through single-nucleus RNA sequencing and fluorescent in situ hybridization techniques, the research will identify molecular markers that distinguish dopamine-only and dopamine-glutamate...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,876 to conduct preclinical trials targeting the neuropeptide S (NPS) receptor to mitigate opioid taking and seeking behaviors in animal models. The goals of the project are to demonstrate proof-of-concept that NPS receptor-targeted molecules can reduce oxycodone self-administration and motivation in rats, which could inform the...
- This federal Project Grant award of $476,496.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at American University investigating the role of opioid signaling in reward-guided decision-making within the rat prefrontal cortex. The project, led by the Principal Investigator, will utilize intra-cortical pharmacology, computational modeling, and video analysis to examine how cortical opioid receptors...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $405,625.00 to Florida International University to investigate the potential benefits of the autophagy activator TFEB in mitigating opioid use disorder (OUD) and overdose in mice. The research aims to evaluate how TFEB overexpression or knockdown impacts opioid-induced effects on mu-opioid receptor desensitization, internalization, and...
This Project Grant award, valued at $190,625.00, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to identify and characterize molecular markers of neuronal inhibition following exposure to opioids, with a focus on the nucleus accumbens region of the brain. Specifically, the research aims to: 1) Identify immediate early genes expressed in response to pharmacological inhibition of the nucleus accumbens, and 2) Identify immediate early genes expressed following pharmacological inhibition with fentanyl. This innovative research is expected to build a foundation for analyzing patterns of excitatory and inhibitory activity in the brain, which could lead to new opportunities for developing treatments for opioid use disorder. The award period runs from September 1, 2025 to August 31, 2027 and will be conducted by researchers at the University of Florida.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $190.6k | 8/20/25 |