Project Grant R21DA061557
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a 5-year Project Grant of $184,706 to the University of North Carolina at Chapel Hill (UNC-CH) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund research to investigate the impact of fentanyl consumption on noradrenergic plasticity in the basolateral amygdala, a key component of the stress response. Specifically, the project will develop a mouse model of...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $192,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Wayne State University. The grant supports a 2-year study to measure the effects of gestational fentanyl exposure on offspring in a rodent model. The research aims to determine the impact on morbidity, mortality, developmental milestones, external morphology, blood cholesterol, brain morphology and...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $305,369 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Taesun, LLC in Colorado. The grant, with a period of performance from August 1, 2025 to January 31, 2026, is for the development of a comprehensive device that integrates fentanyl test strips with sample preparation features to enable convenient and discreet fentanyl testing in high-risk environments....
- The National Institute on Drug Abuse (NIDA) awarded a $915,478 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Brown University to evaluate the effectiveness and safety of different methadone treatment strategies, including dosing and expanded take-home flexibilities, for patients with opioid use disorder in the era of fentanyl. The project aims to address challenges in methadone initiation and maintenance for individuals with a history of fentanyl use, as...
- This federal Project Grant award for $340,000 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research to better understand the role of the locus coeruleus-noradrenergic (LC-NE) system in fentanyl withdrawal-induced negative affect behaviors. The research aims to determine whether a newly identified midbrain glutamatergic input to the LC contributes to the negative affective behaviors associated with opioid withdrawal....
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), part of the U.S. Department of Health and Human Services, is funded through the Drug Use and Addiction Research Programs (CFDA 93.279). The $454,251 award will support the development of a new approach for long-term monitoring of opioid-induced changes in neural population activity and opioid receptor gene expression in mice exposed to fentanyl. Specifically, the project aims to create "erasable"...
- This federal Project Grant award of $457,701 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to understand the pharmacodynamics of combined methamphetamine and fentanyl use. The primary objectives are to: 1) elucidate the mechanisms underlying polysubstance use disorders involving stimulants and opioids, and 2) investigate the role of the hypocretin/orexin neuropeptide system as a potential target for...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $139,927 to the University of Washington to study the impact of chronic, voluntary fentanyl intake on gene expression and neural activity patterns in the brain. The key objectives are to: 1) Conduct single-cell RNA sequencing analysis of the nucleus accumbens to assess changes in gene expression following chronic fentanyl self-administration and...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $147,486 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Trustees of the University of Pennsylvania. This 2.5-year grant, active from July 2025 to January 2028, will support research to determine how individual differences in stress susceptibility influence subsequent opioid use and the role of mu-opioid receptor-expressing neurons in the paraventricular...
- This Project Grant award of $587,188.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a multi-omics research study on the impact of fentanyl use on cells susceptible to HIV infection. The research aims to evaluate the effects of fentanyl on the single-cell transcriptome and microRNA profiles in various peripheral blood mononuclear cell types, including CD4+ and CD8+ T lymphocytes, monocytes, B lymphocytes, dendritic...
The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $193,250 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Trustees of Tufts College, doing business as Tufts University School of Medicine in Boston, Massachusetts. The grant, awarded on September 15, 2025, aims to determine whether fentanyl overdose induces an anhedonic phenotype, which in turn increases the risk of relapse in individuals with opioid use disorder. The research project will utilize a fentanyl overdose model in rats to investigate the underlying neural mechanisms driving persistent decreases in reward motivation and the potential link to relapse. The findings from this R21 proposal are expected to provide crucial insights into the neurobehavioral effects associated with fentanyl overdose and inform the development of targeted interventions to address the opioid overdose crisis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $193.3k | 9/2/25 |