Project Grant R21DA061481
Award Date
9/1/24
Completion Date
8/31/26
Dollars Obligated
$271K
Federal Agency
National Institute on Drug Abuse
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Pasadena, CA 91125, USA
Similar Awards
This $284,040 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to conduct integrated single-cell and spatial mapping of the habenula circuitry to identify projection-specific molecular pathways associated with opioid exposure. The Lieber Institute for Brain Development in Baltimore, MD will lead this research effort from September 1, 2024 to August 31, 2026. The project will generate a...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $445,500.00 to the University of Alabama at Birmingham (UAB) to conduct high-throughput identification and characterization of conserved regulators of drug-induced plasticity in the Caenorhabditis elegans nervous system. The goal is to generate comprehensive molecular, behavioral, and neuronal activity atlases in response to acute and...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop a genetically encoded hydrophobicity biosensor to monitor the dynamic changes in hydrophobicity within biomolecular condensates in living cells. The $216,315 award, active from September 1, 2024, to August 31, 2026, will support the creation of a recombinant protein sensor that uses Förster resonance energy transfer (FRET) to report on...
This federal Project Grant award of $811,112 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research by the University of California, San Francisco (UCSF) to investigate the brain networks and neural signaling mechanisms that underlie sudden "insight" learning of cue-reward associations. The key objectives are to use advanced techniques like two-photon calcium imaging, high-density...
This federal Project Grant award of $800,617.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports the development and validation of neuromarkers - measurable, brain-based indicators of pathophysiology, risk, and resilience related to substance use disorders (SUDs). The project, titled "NEUROMARKERS FOR CRAVING AND DRUG USE", aims to build upon previous research that created a cross-validated neuromarker...
This Project Grant award of $558,668 from the National Institute on Drug Abuse (NIDA) under CFDA Program 93.279 - Drug Use and Addiction Research Programs supports research to elucidate the shared and distinct molecular mechanisms underlying the interplay between HIV, substance use disorders (SUD), and neuropsychiatric/neurodegenerative conditions. The award to Massachusetts Institute of Technology (MIT) aims to leverage single-cell transcriptomic, epigenomic, and spatial datasets along with...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop methods for integrating large-scale electron microscopy (EM) brain imaging data with functional and behavioral recordings. The $1,100,864 project, spanning from September 30, 2024 to September 29, 2027, will focus on relating the structure and function of neural circuits in the Drosophila brain. The proposed research seeks to...
This Project Grant award of $134,556 was provided by the National Institute on Drug Abuse (NIDA) under the federal Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research to determine the role of a specific subpopulation of astrocytes (CRYM+ astrocytes) within the nucleus accumbens (NAc) region of the brain and their contribution to goal-directed behaviors and opioid use disorder. The research aims to characterize the basic biological properties of NAc astrocytes,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $267,310 to the University of Miami to assess the functional role of calcitonin gene-related peptide (CGRP) expressing neurons within the parabrachial nucleus (CGRPPBN) in opioid reinforcement and to determine the associated gene expression and epigenetic changes. The goal is to explore non-opioid targets to treat opioid use disorder, a...