This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $1,478,199 to the University of California, San Diego (UCSD) from July 1, 2024 through April 30, 2029. The project aims to investigate the differential roles of distinct interneuron populations within the infralimbic (ventral) prefrontal cortex in regulating drug-seeking behavior and extinction after cocaine withdrawal. Key activities include...
The National Institute on Drug Abuse (NIDA) awarded a $1,039,420 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to the Medical University of South Carolina (MUSC) to conduct research on the neural circuits underlying the facilitation and disinhibition of opioid and alcohol seeking behaviors. The project will use innovative tools like single-nucleus RNA sequencing, spatial sequencing, in vivo calcium imaging, and holographic optogenetics to characterize the...
This $201,250 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to characterize the synaptic organization and connectivity of cholinergic interneurons in the nucleus accumbens (NAc) core region of the mouse brain. The research, conducted by New York University (NYU), aims to use a combination of anatomical, electrophysiological, and optogenetic techniques to map the diverse...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $373,300.00 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the role of the nucleus accumbens in cue-reward learning. The study aims to investigate how precisely timed inhibition of specific neuronal populations in the nucleus accumbens contributes to the selective learning and response to...
This $562,014 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the role of the medial habenula and interpeduncular nucleus circuit in opioid dependence and withdrawal. The 5-year project, running from September 2024 to July 2029, will use molecular, physiological, and behavioral approaches to determine how mu-opioid receptor signaling in this circuit influences its function and...
The National Institute on Drug Abuse (NIDA) awarded a $267,310 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Miami. The grant aims to assess the functional role of calcitonin gene-related peptide (CGRP) expressing neurons in the parabrachial nucleus (CGRPPBN) in opioid reinforcement and withdrawal, as well as determine the associated gene expression and epigenetic changes. The research will explore the feasibility of targeting these neurons...
This federal Project Grant award of $148,568, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to dissect the mechanisms of dopamine transmission and its role in reward-related behaviors. The award aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, which is critical for motivation, reward learning, and decision-making. The project will explore how...
The National Institute on Drug Abuse (NIDA) awarded a 5-year, $445,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Alabama at Birmingham (UAB). The grant aims to use the nematode worm Caenorhabditis elegans as a model system to conduct high-throughput screening and characterization of genetic regulators underlying drug-induced neuroplasticity and substance use disorder. By generating comprehensive molecular, behavioral, and neuronal...
The National Institute on Drug Abuse (NIDA) awarded a $1,073,250 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of California, San Diego (UCSD) to conduct research on opioid self-administration in middle-aged rats. The research aims to investigate age-related differences in the effects of opioids on locomotion, nociception, and thermoregulation, as well as model opioid reward, acquisition, and escalation in young-adult and middle-aged rats. The...
This Project Grant award of $271,422.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to develop new frameworks for measuring biomolecular condensates (BMCs) and understanding their role in regulating gene expression in olfactory neurons. The objectives are to: (1) define the spatial and molecular composition of BMCs in olfactory neurons, (2) create a neural network model to identify critical components for BMC...