This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the comorbidity of HIV and cocaine use disorders. The $157,568 award, effective from November 13, 2024 to June 30, 2026, will be used by Drexel University to conduct studies that utilize circuit-specific optogenetics and chemogenetics to understand how HIV infection and...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to investigate the effects of HIV infection on astrocytic regulation of stress-induced cocaine reinstatement in male and female mice. The award of $151,500 will fund a study conducted by Drexel University that aims to: 1) determine the effects of EcoHIV inoculation on stress-induced corticosterone levels and astrocytic...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,470 to Drexel University to develop a new imaging pipeline to examine epigenetic spatial architecture in the central nervous system (CNS) of mice with HIV infection that self-administer cocaine. The goal is to understand the mechanisms by which HIV infection enhances the neurobehavioral effects of cocaine, with a focus on the role of histone...
This federal Project Grant award, valued at $5,147,311 and issued by the National Institute on Drug Abuse (NIDA, CFDA 93.279 - Drug Use and Addiction Research Programs), supports research to investigate the impact of HIV infection and cocaine use on the integrity of the blood-brain barrier (BBB) in people living with HIV (PLWH). The key objectives are to: 1) Determine how immune cell phenotypes and HIV proviral DNA burden in monocytes and T cells contribute to BBB permeability in PLWH with and...
This $695,250 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the role of endothelial injury and myeloid cell migration in the activation of inflammasomes in HIV infection and cocaine exposure. The research, led by Howard University, aims to characterize myeloid cell populations in the brains of HIV-transgenic mice under chronic cocaine treatment, and evaluate the accumulation of...
This $134,753 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to determine the mechanisms by which cocaine alters striatal enkephalin levels and the resulting impact on striatal-pallidal circuit activity and cocaine seeking behaviors. The key objectives are to 1) establish the necessity of striatal enkephalin in cocaine-induced adaptations in the striatopallidal circuit through electrophysiology and...
This federal Project Grant award for $149,284 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to define how chronic cocaine use disrupts the regulation of striatal neural activity by dopamine. The key products and services to be delivered include: Employing single-cell calcium imaging and optogenetic manipulation to establish the temporal parameters under which dopamine release modulates the activity of D1 and D2-containing...
This federal Project Grant award of $180,646 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support an investigation into the molecular mechanisms underlying the regulation of cocaine drug-seeking behavior by astrocytic CREB (cAMP response element-binding protein). The research aims to elucidate the astrocyte transcriptome and its epigenetic regulation in the context of drug addiction, with a focus on uncovering...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $441,154 to investigate the molecular mechanisms by which HIV, cocaine, and antiretroviral therapy (ART) interact to drive neuroinflammation through microglial pyroptosis. The research aims to elucidate how these factors collectively contribute to microglial activation and exacerbate neuroinflammation, a significant challenge in managing...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $939,459 over 5 years starting May 1, 2024 to the University of Maryland, Baltimore. The project aims to investigate whether a Contingency Management (CM) intervention can decrease cocaine use and slow cognitive decline among African American cocaine users living with HIV. The key products and services to be delivered include: Evaluating the...