Project Grant R21CA313195
- Federal Grant Award Summary The University of Minnesota, through its Office of Sponsored Projects Administration, received a $573,262 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective April 17, 2026, with completion targeted for March 31, 2031. The award supports the development of innovative autologous humanized patient-derived xenograft (PDX) models designed to advance preclinical testing of immunotherapies for...
- Federal Grant Award Summary The University of Minnesota, through its Office of Sponsored Projects Administration, received a $399,852 Project Grant award from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), effective May 1, 2026 through April 30, 2028. The research project investigates circulating senescent-associated secretory phenotype (SASP) proteins and their relationship to age-related health outcomes in cancer survivors. The project...
- Federal Grant Award Summary The National Cancer Institute awarded a $105,189 Project Grant to the Regents of the University of Minnesota under the Cancer Research Manpower program (CFDA 93.398) effective December 1, 2025, with completion targeted for June 30, 2027. This award funds research aimed at deciphering the structural dynamics and inhibition mechanisms of APOBEC3A (A3A) and APOBEC3B (A3B) enzymes, which play dual roles in host antiviral defense and genomic stability while contributing to...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $119,858 to the Regents of the University of Minnesota under the Cancer Biology Research program (CFDA 93.396) on August 7, 2025, for a project extending through July 31, 2030. This project grant supports fundamental research aimed at elucidating and overcoming T cell dysfunction in pancreatic ductal adenocarcinoma (PDA), a disease notoriously resistant to immunotherapy. The research program comprises three...
- Federal Grant Award Summary The National Cancer Institute awarded the Regents of the University of Minnesota a $395,973 Project Grant on September 5, 2025, under the Cancer Treatment Research program (CFDA 93.395) to develop deazaflavin analog compounds as selective multidrug resistance protein 1 (MRP1) inhibitors for cancer chemosensitization. The research addresses multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters, which represents a major barrier to effective...
- Federal Project Grant Award Summary The University of Minnesota, through its Office of Sponsored Projects Administration, received a $386,879 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026 through February 28, 2031. The award funds fundamental research investigating the mechanisms of nucleosome dynamics in epigenetic inheritance, specifically examining how chromatin...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $418,176.00 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This three-year award supports the advanced development and validation of programmable nucleic acid cytometry, a technology designed to isolate and profile rare cell populations from tumors and tissues. Building on the...
- Federal Project Grant Award Summary The University of Minnesota's Office of Sponsored Projects Administration received a $404,058 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through June 30, 2030. This award supports fundamental biomedical research investigating single-molecule imaging and the mechanisms of crossover regulation on meiotic chromosomes. The...
- Federal Grant Award Summary The University of Minnesota's Regents received a $188,627 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2030. The award supports the development and refinement of KINATEST-ID, a platform technology designed to measure post-translational modification enzyme activity, specifically kinase activity, both in...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Minnesota a $309,761 Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective May 1, 2026, through April 30, 2031. The award funds development and delivery of an innovative training course designed to build capacity in biomarker development and application for cancer prevention research. The University of Minnesota's Masonic Cancer Center will provide both virtual...
The University of Minnesota's Office of Sponsored Projects Administration received a $406,325 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on May 7, 2026, with an ultimate completion date of April 30, 2028. This collaborative research initiative, conducted in partnership between Dr. Xiaokang Lun's laboratory at the University of Minnesota and Dr. Jellert Gaublomme's laboratory at Columbia University, delivers the development and application of CRISPRMap-CyTOF, a novel single-cell screening platform that integrates high-complexity pooled CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) perturbations with mass cytometry-based protein profiling. The platform enables simultaneous decoding of thousands of gene perturbations while quantifying 30 protein or phospho-epitope markers in individual cells across millions of cells in a single-step, high-throughput readout. Deliverables include the re-engineering of the CRISPRMap combinatorial barcoding strategy for mass cytometry compatibility and systematic profiling of early and late signaling responses to kinome-scale CRISPR knockout libraries in chronic myeloid leukemia cells, with and without tyrosine kinase inhibitor treatment. These outputs are intended to identify kinases driving disease progression, uncover novel drug resistance mechanisms, and advance cancer biology understanding through proteome-resolved CRISPR screens at single-cell resolution.Summary of Federal Project Grant Award
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $406.3k | 5/7/26 |