Project Grant R21CA301160
- The National Cancer Institute awarded the Regents of the University of Minnesota a $386,612 Project Grant effective August 13, 2025, through July 31, 2027, under the Cancer Cause and Prevention Research program (CFDA 93.393). This R21 exploratory/developmental grant supports research investigating how social and structural determinants of health (SSDOH) contribute to accelerated biological aging and cancer risk disparities among middle-aged and older adults. The project leverages existing data...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $1,302,284 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) to the Regents of the University of Minnesota, effective May 6, 2025 through April 30, 2030. This research initiative investigates socioeconomic and stress-related immunobiological factors affecting pediatric hematopoietic cell transplant (HCT) outcomes. The primary deliverables include research findings quantifying the...
- Federal Grant Award Summary The National Cancer Institute awarded a $105,189 Project Grant to the Regents of the University of Minnesota under the Cancer Research Manpower program (CFDA 93.398) effective December 1, 2025, with completion targeted for June 30, 2027. This award funds research aimed at deciphering the structural dynamics and inhibition mechanisms of APOBEC3A (A3A) and APOBEC3B (A3B) enzymes, which play dual roles in host antiviral defense and genomic stability while contributing to...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $119,858 to the Regents of the University of Minnesota under the Cancer Biology Research program (CFDA 93.396) on August 7, 2025, for a project extending through July 31, 2030. This project grant supports fundamental research aimed at elucidating and overcoming T cell dysfunction in pancreatic ductal adenocarcinoma (PDA), a disease notoriously resistant to immunotherapy. The research program comprises three...
- Federal Project Grant Award Summary The National Cancer Institute awarded the Regents of the University of Minnesota a $573,262 Project Grant under the Cancer Biology Research program (CFDA 93.396) on April 17, 2026, with completion targeted for March 31, 2031. This award funds the development of autologous humanized leukemia models for immunotherapy testing—specifically, the creation of patient-derived xenograft (PDX) models that incorporate both leukemia cells and immune cells derived from the...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $423,500 to the Regents of the University of Minnesota (Office of Sponsored Projects Administration) under the Aging Research program (CFDA 93.866) for a project titled "Exploring the Links Between Cyclin D1, Metabolism and Aging." The award period runs from February 1, 2026, through January 31, 2028. The research aims to elucidate the mechanisms linking the cell cycle protein cyclin D1 to age-related...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Minnesota a $309,761 Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective May 1, 2026, through April 30, 2031. The award funds development and delivery of an innovative training course in biomarker development and applications for cancer prevention research. The course combines virtual didactic modules on chemical carcinogenesis fundamentals with a five-week...
- Federal Project Grant Award Summary The National Cancer Institute awarded $395,973 to the University of Minnesota (Regents of the University of Minnesota) under the Cancer Treatment Research program (CFDA 93.395) for a project focused on developing deazaflavin analogs as selective multidrug resistance protein 1 (MRP1) inhibitors for cancer chemosensitization. The award period runs from September 5, 2025 through August 31, 2027. The project delivers research and development services aimed at...
- Federal Grant Award Summary The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), awarded a Project Grant of $762,675 to Fred Hutchinson Cancer Center (doing business as Seattle Cancer Care Alliance) on April 15, 2026, with a completion date of March 31, 2031. This research initiative investigates immune aging phenotypes in adult survivors of childhood hematologic malignancies, specifically examining how the immune system changes in long-term cancer survivors and...
- Federal Grant Award Summary The National Cancer Institute awarded $386,700 to the Regents of the University of Minnesota under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on July 7, 2025, for preclinical development and validation of targeted mass spectrometry assays for serous ovarian cancer diagnosis. The project, which runs through June 30, 2027, will deliver novel parallel reaction monitoring (PRM) assays capable of differentiating serous ovarian cancer patients from...
The National Cancer Institute awarded a Project Grant of $399,852.00 to the Regents of the University of Minnesota under the Cancer Cause and Prevention Research program (CFDA 93.393) for the period May 1, 2026, through April 30, 2028. This research initiative will develop and validate circulating senescent-associated secretory phenotype (SASP) protein indexes to assess accelerated aging in cancer survivors. The primary deliverable involves creating cross-sectional and longitudinal SASP indexes using proteomic data from approximately 5,000 proteins measured through the SOMAscan assay in the Atherosclerosis Risk in the Community (ARIC) cohort, incorporating 133 functionally meaningful proteins identified in the published atlas of soluble SASP proteins. The research will apply these validated indexes to examine associations between circulating SASP proteins and age-related outcomes in cancer survivors, including all-cause mortality, cardiovascular disease risk, frailty progression, and kidney function changes. The study uniquely combines cross-sectional protein characteristics with rate-of-change metrics in a longitudinal index designed to better reflect the aging process than existing cross-sectional approaches. Research will be performed at the University of Minnesota's Minneapolis facility, with indexes developed and internally validated in cancer-free participants before application to cancer survivor populations to establish clinically relevant biomarkers for accelerated aging in this vulnerable population.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.9k | 4/10/26 |