Project Grant R21CA307778
- Federal Grant Award Summary The National Cancer Institute awarded a $661,721 Project Grant to the University of California, San Diego, under the Cancer Biology Research program (CFDA 93.396), effective April 1, 2026 through March 31, 2031. The award supports fundamental research focused on systematic functional mapping and interrogation of intrinsically disordered regions (IDRs) in oncogenic proteins. The research employs high-throughput functional screening technologies and computational...
- Federal Grant Award Summary The National Cancer Institute awarded a $410,115 Project Grant to the University of California, San Diego under the Cancer Biology Research program (CFDA 93.396) for the period August 1, 2025 through July 31, 2027. The award supports research focused on developing improved preclinical models for pancreatic ductal adenocarcinoma (PDAC) by incorporating three-dimensional high-density type I collagen (HDC) scaffolding into tumor cell injection protocols. The research...
- Federal Grant Award Summary The University of California, Irvine received a $138,489 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) awarded on September 20, 2025, with a completion date of September 19, 2027. The award supports research and development of a methyl arginine targeting chimera (MARTAc) for the lysosomal degradation of intracellular proteins. This project addresses critical limitations of current proteolysis-targeting...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded UCLA a $649,181 Project Grant effective August 8, 2025, through July 31, 2028, under the Cancer Detection and Diagnosis Research program (CFDA 93.394). This award supports the development of high-throughput multidimensional chemoproteomics technologies for function-directed covalent target discovery in cancer drug development. The research team will establish enhanced sample preparation reagents and custom proteomics...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $615,399 Project Grant to the University of California, Davis under the Cancer Treatment Research program (CFDA 93.395) for the period August 1, 2025, through July 31, 2030. The award supports the development of a transformable nanoparticle (TNP) platform designed to deliver therapeutic peptides and proteins directly to tumor microenvironments on-demand. The TNP technology transforms from nanoparticles to nanofibrils...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded UC San Diego a $988,224 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to advance treatment strategies for head and neck cancer patients with competing health risks through multi-center randomized clinical trials. The four-year award, effective September 1, 2025 through August 31, 2029, supports the principal investigator's clinical research program focused on developing novel alternative therapeutic...
- Federal Grant Award Summary The National Cancer Institute awarded a $410,933 Project Grant (Cancer Treatment Research, CFDA 93.395) to the University of California, San Diego, effective March 18, 2026, through February 29, 2028. This exploratory research initiative (R21 mechanism) aims to develop next-generation small interfering RNA (siRNA) therapeutics to treat metastatic castration-resistant prostate cancer (mCRPC). The project focuses on enhancing siRNA delivery into mCRPC tumor cells by...
- Federal Project Grant Award Summary The University of California, San Francisco received a $421,685 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) to investigate discovery methods for identifying functional immune niches within the tumor microenvironment (TME). Awarded on August 8, 2025, with a completion date of July 31, 2027, this research project will deliver scientific discoveries regarding the cellular and molecular mechanisms that...
- Federal Grant Award Summary The National Cancer Institute awarded a Project Grant of $149,394 to the University of California, Davis, effective August 1, 2025, through July 31, 2030, under the Cancer Detection and Diagnosis Research program (CFDA 93.394). This award supports targeted radiotheranostics research—the development and clinical translation of radiopharmaceuticals that combine diagnostic imaging and therapeutic capabilities for oncology applications. The project focuses on designing,...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $662,682 Project Grant to the University of California, San Diego under the Cancer Treatment Research program (CFDA 93.395) on June 4, 2025, with an ultimate completion date of May 31, 2030. This award funds research investigating the prognostic and therapeutic roles of voltage-gated potassium channels in managing KIT mutant gastrointestinal stromal tumors (GISTs). The project will deliver a Phase 1 neoadjuvant...
The National Cancer Institute (NCI) awarded the University of California, Irvine $403,686 on March 19, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop innovative approaches for enhancing cancer drug efficacy through nutritional modulation. The project, which extends through February 28, 2027, will establish an unbiased genetic screening platform utilizing syngeneic orthotopic pancreatic ductal adenocarcinoma (PDAC) models to systematically evaluate drug-diet interactions across over 2,000 drug targets. The research aims to identify and exploit cancer-specific metabolic vulnerabilities by integrating precision dietary interventions with targeted therapies, with particular focus on treatment-resistant cancers. The deliverables under this award include in vitro screening data characterizing promising drug-diet synergies, in vivo validation studies assessing the impact of dietary modifications on drug efficacy, and a foundational framework for leveraging metabolic stress to enhance existing cancer treatments. By focusing on clinically relevant compounds and personalized dietary strategies, this research is designed to provide rapid translation into novel combination therapies and establish innovative precision medicine approaches in oncology. The work will be conducted at UCI's Irvine, California facility and is expected to contribute to the NCI's broader mission of developing improved cancer treatment methods through fundamental and applied laboratory research.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $403.7k | 3/19/26 |