Project Grant R21CA306936
- Federal Grant Award Summary Yale University received a $610,637 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded April 1, 2026, with completion targeted for March 31, 2031. The grant funds bioengineering research to develop an optimized drug delivery platform utilizing bioadhesive and non-adhesive biodegradable nanoparticles for locoregional treatment of advanced melanoma. The research will engineer nanoparticles with selective...
- Federal Grant Award Summary Yale University received a $672,371 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective September 1, 2025, through August 31, 2028. The grant funds development of ultra-sensitive mass spectrometry-based immunopeptidomics technology utilizing digital microfluidics to identify tumor-specific antigens (TSAs) for cancer immunotherapy applications. The project addresses current...
- Federal Grant Award Summary The National Cancer Institute awarded Yale University a $478,532 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This research initiative will investigate the biological and clinical significance of spatial immune heterogeneity in non-small cell lung cancer (NSCLC), with particular focus on characterizing how the spatial distribution of tumor-infiltrating lymphocytes (TILs) and tertiary...
- Federal Grant Award Summary Yale University received a $167,771 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded August 1, 2025, with completion targeted for July 31, 2027. The award supports research to elucidate the mechanisms of a novel human-specific immune checkpoint interaction between SIGLEC-7 and VSIG4 proteins. The research will utilize a humanized mouse platform (MISTRG6-A2) to develop in vivo models that investigate how...
- Federal Grant Award Summary Yale University received a $150,104 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded January 16, 2026, with a completion date of August 31, 2028. This award supports research investigating the impact of aberrant 5-methylcytosine (M5C) messenger RNA (mRNA) modifications on translation initiation and cancer development. The research focuses on determining how dose-sensitive M5C modifications in...
- Federal Grant Award Summary The National Cancer Institute awarded Yale University a $295,192 Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective July 1, 2026 through June 30, 2031. This award supports Dr. Goran Micevic's career development as an independent investigator in basic and translational tumor immunology, epigenetics, and spatial transcriptomics. The research focuses on enhancing melanoma adoptive immunotherapy by identifying and epigenetically reprogramming...
- Federal Grant Award Summary Yale University received a $607,690 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) awarded on May 6, 2026, with a completion date of April 30, 2031. The grant funds development of an magnetic resonance (MR)-based imaging platform for high-resolution simultaneous intracellular pH (PHI) and extracellular pH (PHE) imaging in glioblastoma multiforme (GBM), an aggressive and chemotherapy-resistant...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Yale University a $290,944 mentored clinical scientist research career development grant (Cancer Research Manpower program, CFDA 93.398) effective August 1, 2026, through July 31, 2031. This award supports a comprehensive training program enabling Dr. Benjamin Y. Lu to prepare for an independent academic research career as a physician-scientist while investigating immune checkpoint regulation in glioblastoma (GBM), the...
- Federal Project Grant Award Summary Yale University received a $192,564 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective September 1, 2025 through August 31, 2028. The award supports the development of innovative dual-target Protease Targeted Chimera (PROTAC)-based protein degraders designed to overcome therapy resistance in metastatic castration-resistant prostate cancer (MCRPC). The research addresses lineage...
- Federal Grant Award Summary Yale University received a $1.3 million Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) effective July 1, 2025 through June 30, 2029. The award supports the development of GUAR-T as a novel class of universal cellular immunotherapies for ovarian cancer. This research initiative represents a hypothesis-driven translational effort aimed at advancing cancer immunotherapy to address critical...
Yale University received a $432,125 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) to develop engineered Salmonella-based immunotherapy platforms for treating immunologically silent tumors. The award, effective June 1, 2026 through May 31, 2028, supports research to advance bacterial-based cancer therapies by addressing key limitations in current approaches. The research deliverables include the development of novel innate immune stimulation mechanisms to overcome tumor resistance, creation of safer bacterial minicells that maintain immunostimulatory capacity, and engineering of Salmonella vectors capable of delivering tumor-specific antigens to engage CD8+ T cells for targeted immune responses against antigenically diverse solid tumors. The project directly addresses unmet clinical needs by transforming Salmonella enterica serovar Typhimurium into a next-generation therapeutic platform that overcomes systemic toxicity risks while improving efficacy against immunologically cold tumors resistant to conventional immunotherapy. Research will be conducted at Yale University's New Haven, Connecticut facility and is expected to generate scientific findings and technological innovations applicable to future clinical applications of bacterial-based cancer therapies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $432.1k | 5/19/26 |