Project Grant R21CA305308
- Summary of Federal Project Grant Award Award Details: The National Cancer Institute (NCI) awarded $157,000 in project grant funding (CFDA 93.395, Cancer Treatment Research) to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, effective July 1, 2026, through June 30, 2028. The research will be conducted in Cleveland, Ohio. Products and Services: This project grant supports research to identify and characterize gut bacterial species that can modulate immune checkpoint...
- Federal Project Grant Award Summary Funding Agency: National Cancer Institute (NCI) Federal Grant Program: Cancer Biology Research (CFDA 93.396) Award Amount: $510,650 Award Period: September 1, 2025 – August 31, 2030 Awardee: Case Western Reserve University, Office of Research Administration (in affiliation with University Hospitals of Cleveland) Case Western Reserve University will conduct a five-year research project investigating biological factors that drive clinical outcomes in human...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a Project Grant of $640,775 under the Cancer Treatment Research program (CFDA 93.395) on June 22, 2026, with a completion date of May 31, 2031. The grant supports a co-clinical trial investigating the role of intratumoral bacteria in driving immunosuppression and immune checkpoint inhibitor (ICI) resistance in head and neck squamous cell carcinoma...
- Federal Project Grant Award Summary Award Details: Case Western Reserve University received a $630,108 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded March 13, 2026, with completion targeted for February 28, 2030. The research will be conducted in Cleveland, Ohio in affiliation with University Hospitals of Cleveland. Research Scope and Deliverables: This project develops and validates theranostic...
- Federal Project Grant Award Summary Case Western Reserve University received a $147,486 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded December 1, 2025, with completion targeted for May 31, 2027. The award supports the development of a pathologically interpretable computational imaging predictor to identify rectal cancer patients exhibiting complete response (CR) to total neoadjuvant therapy (TNT) who are candidates for...
- Federal Grant Award Summary The National Cancer Institute awarded the Regents of the University of Michigan a $2.86 million Project Grant under the Cancer Treatment Research program (CFDA 93.395) to develop and validate a novel microbial-based therapeutic strategy targeting colibactin, a carcinogenic metabolite produced by pathogenic gut bacteria associated with colorectal cancer (CRC). The project, which commenced September 10, 2025, and extends through August 31, 2029, focuses on engineering...
- Federal Project Grant Award Summary Case Western Reserve University received a $109,076 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded January 16, 2026, with completion targeted for August 31, 2029. The award supports research investigating the role of B-cell Activating Factor (BAFF) in adverse events associated with Chimeric Antigen Receptor (CAR)-T cell therapy. Specifically, the research examines BAFF's involvement in...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $484,918 to the University of Connecticut Health Center under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2026, through May 31, 2031. This five-year project grant supports fundamental research investigating how the IL-17-YBX1 signaling pathway controls tumor-infiltrating regulatory T cell (Treg) function in colorectal cancer (CRC) development. The research aims to elucidate the protective role...
- Federal Project Grant Award Summary The National Cancer Institute awarded $671,226 to the University of California, San Diego on May 15, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop engineered native bacteria-based therapies for colorectal cancer prevention and treatment. The project, with an ultimate completion date of April 30, 2031, focuses on creating a microbial platform utilizing host-derived E. coli strains that can durably colonize the gastrointestinal...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), through its Cancer Research Manpower program (CFDA 93.398), awarded The Washington University a Project Grant of $333,504 effective July 1, 2025, through July 31, 2027. This award funds research investigating the dynamics and function of peritoneal myeloid cells during colorectal cancer (CRC) peritoneal dissemination and the implications for immunotherapy. The research aims to elucidate the unique roles of myeloid...
Case Western Reserve University's Office of Research Administration received a $403,686 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) for the period July 1, 2026, through June 30, 2028. The award supports research to characterize IL-33-responsive mucosal cells and their role in colitis-associated cancer (CAC) development. The project addresses the critical gap in understanding how ulcerative colitis (UC), a chronic inflammatory disorder affecting the colon and rectum, progresses to colorectal cancer, which currently carries elevated mortality risk in affected patients despite improved screening and therapeutic interventions. The research deliverables include identification and functional characterization of ST2-expressing, IL-33-responsive cells in the gut mucosa using two established mouse models—AOM/DSS-treated and Winnie mice. The study will elucidate the dichotomous role of the IL-33/ST2 signaling axis in the tumor microenvironment, examining how various cell populations (subepithelial myofibroblasts, mast cells, T regulatory cells, and eosinophils) either promote or prevent CAC progression. Findings from this exploratory research are expected to yield fundamental insights into inflammation-associated carcinogenesis mechanisms and potentially inform novel prevention and treatment strategies for UC patients at risk of developing colorectal cancer.Summary of Federal Project Grant Award
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $403.7k | 6/30/26 |